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Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance. 2012

Luke F Chen, and Deverick J Anderson, and David L Paterson
Duke Program for Infection Prevention and Healthcare Epidemiology, Durham, NC, USA ; Duke Infection Control Outreach Network, Durham, NC, USA ; Duke University Prevention Epicenter Program, Durham, NC, USA ; Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Klebsiella pneumoniae carbapenemases (KPCs) confer resistance to nearly all β-lactams. This broad-spectrum drug resistance mechanism has rapidly spread in the United States and is reportedly increasing elsewhere in the world. Thus, the emergence of KPC resistance is a major threat to global health. This article reviews the epidemiology and provides an overview of the dissemination of KPC-producing organisms.

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