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[Influence of infant formula on reproductive development of rats]. 2012

Yong Xue, and Xianglong Shao, and Defu Ma, and Zhaoyan Liu, and Yanli Lv, and Yang Wang, and Yumei Zhang, and Peiyu Wang
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China. ywzj552211@163.com

OBJECTIVE To identify the effects of infant formula on the reproductive development of Spraque-Dawley rats. METHODS A two-generation reproductive test was carried out. Forty 4 week-old SD rats were divided into two groups randomly by body weight and maintained on diet containing a kind of infant formula or an adjusted basal feeds. The body weight, dietary intake, hormone level, function of reproductive organs, and the development status of the P generation rats and F1 generation rats were measured. RESULTS No significant growth-promoting effect was observed in the infant formula group; and no impairment on reproductive organ development or development status in the P generation and F1 generation rats was caused by the infant formula. The body weight at the 14th day of gestation and at the 0th and 4th day of lactation in infant formula group was significantly lower than that in control group (P < 0.05). The level of prolactin was significantly lower in the infant formula group. The AGD of F2a female rats was significantly shorter in the infant formula group. CONCLUSIONS There was few effect of the infant formula on the reproductive development of SD rats, further study is required to determine the effects of infant formula on the body weight change during gestation period and lactation period, AGD and prolactin level.

UI MeSH Term Description Entries
D007774 Lactation The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN. Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D012098 Reproduction The total process by which organisms produce offspring. (Stedman, 25th ed) Human Reproductive Index,Human Reproductive Indexes,Reproductive Period,Human Reproductive Indices,Index, Human Reproductive,Indexes, Human Reproductive,Indices, Human Reproductive,Period, Reproductive,Periods, Reproductive,Reproductive Index, Human,Reproductive Indices, Human,Reproductive Periods
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D005260 Female Females
D006066 Gonads The gamete-producing glands, OVARY or TESTIS. Gonad
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D041943 Infant Formula Formulations for the nutrition of infants that are substituted for BREAST MILK. Baby Formula,Baby Formulas,Formula, Baby,Formula, Infant,Formulas, Baby,Formulas, Infant,Infant Formulas
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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