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The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN. 2013
Satoko Kojima, and
Kei Kawana, and
Kensuke Tomio, and
Aki Yamashita, and
Ayumi Taguchi, and
Shiho Miura, and
Katsuyuki Adachi, and
Takeshi Nagamatsu, and
Kazunori Nagasaka, and
Yoko Matsumoto, and
Takahide Arimoto, and
Katsutoshi Oda, and
Osamu Wada-Hiraike, and
Tetsu Yano, and
Yuji Taketani, and
Tomoyuki Fujii, and
Danny J Schust, and
Shiro Kozuma
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
OBJECTIVE Local adaptive cervical regulatory T cells (Tregs) are the most likely direct suppressors of the immune eradication of cervical intraepithelial lesion (CIN). PD-1 expression on T cells induces Tregs. No studies have quantitatively analyzed the Tregs and PD-1+ cells residing in CIN lesions. METHODS Cervical lymphocytes were collected using cytobrushes from CIN patients and analyzed by FACS analysis. Comparisons were made between populations of cervical Tregs and PD-1+ CD4+ T cells in CIN regressors and non-regressors. RESULTS A median of 11% of cervical CD4+ T cells were Tregs, while a median of 30% were PD-1+ cells. The proportions of cervical CD4+ T cells that were Tregs and/or PD-1+ cells were significantly lower in CIN regressors when compared with non-regressors. CONCLUSIONS The prevalence of cervical tolerogenic T cells correlates inversely with spontaneous regression of CIN. Cervical Tregs may play an important role in HPV-related neoplastic immunoevasion.
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