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The morphological characteristics of three clones of hamster brain cells transformed in vitro by polyoma virus and of the tumors obtained after subcutaneous grafting of these cells in syngenic animals are reported. These clones appeared to be glial in nature by light and electron microscopy. The initial tumors induced by the three clones presented astrocytic features both by electron microscopy and immunohistochemistry. Analysis of the subsequent in vivo passages showed a decrease in cell differentiation, which was accompanied by a decrease in the latency period; after 2 years of serial transplantation, the tumors seemed poorly differentiated gliomas. A control cell line of hamster cerebellar cells evolved similarly.
M F Tripier, and
J Hassoun, and
C de Micco, and
G Meyer, and
M Toga
September 1972,
The Journal of general virology,
M F Tripier, and
J Hassoun, and
C de Micco, and
G Meyer, and
M Toga
January 1975,
Bollettino dell'Istituto sieroterapico milanese,
M F Tripier, and
J Hassoun, and
C de Micco, and
G Meyer, and
M Toga
December 1962,
Virology,
M F Tripier, and
J Hassoun, and
C de Micco, and
G Meyer, and
M Toga
November 1970,
Bollettino della Societa italiana di biologia sperimentale,
M F Tripier, and
J Hassoun, and
C de Micco, and
G Meyer, and
M Toga
March 1964,
Virology,
M F Tripier, and
J Hassoun, and
C de Micco, and
G Meyer, and
M Toga
July 1962,
Virology,
M F Tripier, and
J Hassoun, and
C de Micco, and
G Meyer, and
M Toga
June 1970,
Nihon rinsho. Japanese journal of clinical medicine,
M F Tripier, and
J Hassoun, and
C de Micco, and
G Meyer, and
M Toga
October 1964,
Virology,
M F Tripier, and
J Hassoun, and
C de Micco, and
G Meyer, and
M Toga
April 1964,
Comptes rendus hebdomadaires des seances de l'Academie des sciences,
M F Tripier, and
J Hassoun, and
C de Micco, and
G Meyer, and
M Toga
December 1976,
The Journal of general virology,
