Biomaterial Database

Clinical significance of T-regulatory cells in B-cell non-Hodgkin's lymphoma. 2011

Ahmad Baraka, and Hatem M Salem

Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Regulatory T cells (Tregs) play a central role in protecting the host from autoimmune diseases. However, Tregs also pose a major problem to anti-tumor immunity. The expansion and accumulation of these immunosuppressive cells correlate with advanced tumor growth and predict poor disease prognosis. The study aims at evaluation of the clinical role of regulatory T cells in B-cell Non-Hodgkin's lymphoma. The study was carried out on 45 de novo patients with B- NHL, they included 26 males and 19 females and 20 apparently healthy age-matched as control. Diagnosis of lymphoma was done by lymph node biopsy, 15 patients had diffuse large B cell lymphoma (DLBCL), 9 follicular lymphoma (FL), 8 small cell lymphocytic lymphoma (SCLL), 7 marginal zone lymphoma (MZL) and 6 had mantle cell lymphoma (MCL). Tregs (CD4+CD25+ FoxP+3) were analyzed by Flowcytometry. The mean percent was 10.9 +/- 1.6% in diffuse large B cell lymphoma, 12.4 +/- 1.4% in follicular lymphoma, 13.7 +/- 2.4% in small cell lymphocytic lymphoma, 11.9 +/- 1.9% in marginal zone lymphoma and 13.5 +/- 1.35% in mantle cell lymphoma as compared to 5.9 +/- 0.96% in controls with a significant increase in the patients in relation to control group. Tregs was significantly increased in advanced stages of the disease, in bone marrow infiltration and in patients with increased LDH level. In conclusion, Tregs may play a role in modifying immune responses in patients with lymphomas and may be useful in immunotherapy and new anti-lymphoma strategies involving depletion of Tregs.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D005260	Female		Females
D005434	Flow Cytometry	Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.	Cytofluorometry, Flow,Cytometry, Flow,Flow Microfluorimetry,Fluorescence-Activated Cell Sorting,Microfluorometry, Flow,Cell Sorting, Fluorescence-Activated,Cell Sortings, Fluorescence-Activated,Cytofluorometries, Flow,Cytometries, Flow,Flow Cytofluorometries,Flow Cytofluorometry,Flow Cytometries,Flow Microfluorometries,Flow Microfluorometry,Fluorescence Activated Cell Sorting,Fluorescence-Activated Cell Sortings,Microfluorimetry, Flow,Microfluorometries, Flow,Sorting, Fluorescence-Activated Cell,Sortings, Fluorescence-Activated Cell
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D016393	Lymphoma, B-Cell	A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.	B-Cell Lymphoma,B Cell Lymphoma,B-Cell Lymphomas,Lymphoma, B Cell,Lymphomas, B-Cell
D050378	T-Lymphocytes, Regulatory	CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.	Regulatory T Cell,Regulatory T-Cell,Regulatory T-Lymphocyte,Regulatory T-Lymphocytes,Suppressor T-Lymphocytes, Naturally-Occurring,T-Cells, Regulatory,Th3 Cells,Tr1 Cell,Treg Cell,Regulatory T-Cells,Suppressor T-Cells, Naturally-Occurring,Tr1 Cells,Treg Cells,Cell, Regulatory T,Cell, Th3,Cell, Tr1,Cell, Treg,Cells, Regulatory T,Cells, Th3,Cells, Tr1,Cells, Treg,Naturally-Occurring Suppressor T-Cell,Naturally-Occurring Suppressor T-Cells,Naturally-Occurring Suppressor T-Lymphocyte,Naturally-Occurring Suppressor T-Lymphocytes,Regulatory T Cells,Regulatory T Lymphocyte,Regulatory T Lymphocytes,Suppressor T Cells, Naturally Occurring,Suppressor T Lymphocytes, Naturally Occurring,Suppressor T-Cell, Naturally-Occurring,Suppressor T-Lymphocyte, Naturally-Occurring,T Cell, Regulatory,T Cells, Regulatory,T Lymphocytes, Regulatory,T-Cell, Naturally-Occurring Suppressor,T-Cells, Naturally-Occurring Suppressor,T-Lymphocyte, Regulatory,Th3 Cell