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An inhibitor of interferon action was identified in mouse lymphokine preparations. The inhibito was first detected in the supernatant fluid of mouse spleen cells at 72 h after stimulation by staphylococcal enterotoxin A. Inhibitor was not detected in supernatant fluids from unstimulated cultures. This inhibitor blocks the antiviral activity of both immune and fibroblast interferons. The inhibitor was purified 1,000-fold by two-step column chromatography. The partially purified inhibitor blocked the antiviral activity of up to 400 U of interferon. The immunosuppressive effect of interferon was also blocked by the inhibitor, suggesting that the inhibitor may modulate the immunoregulatory function of interferon.
W R Fleischmann, and
J A Georgiades, and
L C Osborne, and
F Dianzani, and
H M Johnson
January 1984,
Journal of interferon research,
W R Fleischmann, and
J A Georgiades, and
L C Osborne, and
F Dianzani, and
H M Johnson
January 1981,
Texas reports on biology and medicine,
W R Fleischmann, and
J A Georgiades, and
L C Osborne, and
F Dianzani, and
H M Johnson
January 1987,
Voprosy virusologii,
W R Fleischmann, and
J A Georgiades, and
L C Osborne, and
F Dianzani, and
H M Johnson
October 1982,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
W R Fleischmann, and
J A Georgiades, and
L C Osborne, and
F Dianzani, and
H M Johnson
January 1985,
Journal of interferon research,
W R Fleischmann, and
J A Georgiades, and
L C Osborne, and
F Dianzani, and
H M Johnson
January 1985,
Journal of interferon research,
W R Fleischmann, and
J A Georgiades, and
L C Osborne, and
F Dianzani, and
H M Johnson
January 1971,
Annual review of microbiology,
W R Fleischmann, and
J A Georgiades, and
L C Osborne, and
F Dianzani, and
H M Johnson
May 1968,
Acta virologica,
W R Fleischmann, and
J A Georgiades, and
L C Osborne, and
F Dianzani, and
H M Johnson
January 1981,
Methods in enzymology,
W R Fleischmann, and
J A Georgiades, and
L C Osborne, and
F Dianzani, and
H M Johnson
March 1982,
Cellular immunology,
