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New bioactive alkyl sulfates from Mediterranean tunicates. 2012
Concetta Imperatore, and
Anna Aiello, and
Filomena D'Aniello, and
Paolo Luciano, and
Rocco Vitalone, and
Rosaria Meli, and
Giuseppina Mattace Raso, and
Marialuisa Menna
The NeaNat Group, Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.
Chemical investigation of two species of marine ascidians, Aplidium elegans and Ciona edwardsii, collected in Mediterranean area, led to isolation of a series of alkyl sulfates (compounds 1-5) including three new molecules 1-3. Structures of the new metabolites have been elucidated by spectroscopic analysis. Based on previously reported cytotoxic activity of these type of molecules, compounds 1-3 have been tested for their effects on the growth of two cell lines, J774A.1 (BALB/c murine macrophages) and C6 (rat glioma) in vitro. Compounds 1 and 2 induced selective concentration-dependent mortality on J774A.1 cells.
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