Visual and auditory evoked potentials in migraine. 1990

M E Drake, and A Pakalnis, and S A Hietter, and H Padamadan
Ohio State University Hospitals, Department of Neurology, Columbus.

We recorded visual (VEP) and brainstem auditory (BAEP) evoked potentials in 50 patients with clinically diagnosed common migraine attended by visual obscuration or sensory symptoms but no neurologic deficit. VEPs were recorded from Oz, 01, and 02 referenced to Fz, with replication of 200 repetitions of 1.88 per second checkerboard stimuli subtending a 56 minute retinal arc. Analysis time was 250 ms., and filter band pass was 1-250 Hz. BAEPs utilized rarefaction stimulation at 70 dB SL, with 150-3,000 Hz filter band pass and 10 ms. analysis time. Two thousand averages were recorded and replicated from Cz-A1 and Cz-A2. VEP N1, P1 and N2 latencies were longer in migraine patients than in controls, and VEP amplitudes were minimally greater. No significant differences were found between patients and controls, however. BAEP I-V and III-V interpeak latencies were significantly prolonged in migraine patients, and the degree of prolongation was greater on the left. Neither VEPs nor BAEPs exceeded clinical norms in migraine patients. VEPs and BAEPs are likely to add little to the clinical assessment of headache patients. BAEP differences may indicate dysfunction of brainstem centers, possibly related to endorphin or serotonin neurotransmission, and possibly related to the pathogenesis of migraine. The left sided asymmetry has been described previously and is of uncertain significance, but may also support a central mechanism for migraine.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D008881 Migraine Disorders A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1) Acute Confusional Migraine,Headache, Migraine,Status Migrainosus,Abdominal Migraine,Cervical Migraine Syndrome,Hemicrania Migraine,Migraine,Migraine Headache,Migraine Variant,Sick Headache,Abdominal Migraines,Acute Confusional Migraines,Cervical Migraine Syndromes,Disorder, Migraine,Disorders, Migraine,Headache, Sick,Headaches, Migraine,Headaches, Sick,Hemicrania Migraines,Migraine Disorder,Migraine Headaches,Migraine Syndrome, Cervical,Migraine Syndromes, Cervical,Migraine Variants,Migraine, Abdominal,Migraine, Acute Confusional,Migraine, Hemicrania,Migraines,Migraines, Abdominal,Migraines, Acute Confusional,Migraines, Hemicrania,Sick Headaches,Variant, Migraine,Variants, Migraine
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms
D005072 Evoked Potentials, Auditory The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS. Auditory Evoked Potentials,Auditory Evoked Response,Auditory Evoked Potential,Auditory Evoked Responses,Evoked Potential, Auditory,Evoked Response, Auditory,Evoked Responses, Auditory,Potentials, Auditory Evoked
D005074 Evoked Potentials, Visual The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways. Visual Evoked Response,Evoked Potential, Visual,Evoked Response, Visual,Evoked Responses, Visual,Potential, Visual Evoked,Potentials, Visual Evoked,Response, Visual Evoked,Responses, Visual Evoked,Visual Evoked Potential,Visual Evoked Potentials,Visual Evoked Responses
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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