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Expression of the CLOCK, BMAL1, and PER1 circadian genes in human oral mucosa cells as dependent on CLOCK gene polymorphic variants. 2012

I V Kurbatova, and S N Kolomeichuk, and L V Topchieva, and V A Korneva, and N N Nemova
Karelian Scientific Center, Russian Academy of Sciences, Petrozavodsk, Russia.

UI MeSH Term Description Entries
D009061 Mouth Mucosa Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations. Buccal Mucosa,Oral Mucosa,Mucosa, Mouth,Mucosa, Oral
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D056926 CLOCK Proteins Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins. CLOCK Protein,Circadian Locomotor Output Cycles Kaput Proteins
D056930 ARNTL Transcription Factors Basic helix-loop-helix (bHLH) domain-containing proteins that play important roles in CIRCADIAN RHYTHM regulation. They combine with CLOCK PROTEINS to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. ARNTL1 Protein,ARNTL2 Protein,Aryl Hydrocarbon Receptor Nuclear Translocator-like 1 Protein,Aryl Hydrocarbon Receptor Nuclear Translocator-like 2 Protein,Aryl Hydrocarbon Receptor Nuclear Translocator-like Protein 1,Aryl Hydrocarbon Receptor Nuclear Translocator-like Transcription Factors,BMAL1 Protein,BMAL2 Protein,Brain and Muscle ARNT-like 2 Protein,Brain and Muscle ARNT-like Proteins,Brain and muscle ARNT-like 1 Protein,MOP3 Transcription Factor,MOP9 Transcription Factor,Member of PAS Protein 3,Member of PAS Protein 9,Aryl Hydrocarbon Receptor Nuclear Translocator like 1 Protein,Aryl Hydrocarbon Receptor Nuclear Translocator like 2 Protein,Aryl Hydrocarbon Receptor Nuclear Translocator like Protein 1,Aryl Hydrocarbon Receptor Nuclear Translocator like Transcription Factors,Brain and Muscle ARNT like 2 Protein,Brain and Muscle ARNT like Proteins,Brain and muscle ARNT like 1 Protein,Transcription Factor, MOP9,Transcription Factors, ARNTL
D056950 Period Circadian Proteins Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS. Circadian Clock Protein Period,Circadian Clock Protein Period 1,Circadian Clock Protein Period 2,Circadian Clock Protein Period 3,Circadian Pacemaker Protein Rigui,Period Circadian Protein 1,Period Circadian Protein 2,Period Circadian Protein 3,Period Proteins
D020641 Polymorphism, Single Nucleotide A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population. SNPs,Single Nucleotide Polymorphism,Nucleotide Polymorphism, Single,Nucleotide Polymorphisms, Single,Polymorphisms, Single Nucleotide,Single Nucleotide Polymorphisms

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