Biomaterial Database

Embryo implantation associated with increase in T-cell suppressor factor in the uterus and spleen of mice. 1990

R C Hoversland, and K D Beaman

Department of Anatomy, Indiana University School of Medicine, Fort Wayne 46805-1499.

The concentrations of T-cell suppressor factor (TsF) were examined by competitive binding assays in the uterus, spleen, and regional lymph nodes draining the uterus in Day-5 pregnant mice or in ovariectomized mice given hormone treatments to induce conditions of delayed implantation or implantation. The amounts of immunoreactive TsF on Day 5 of pregnancy were 2.055 +/- 0.302, 0.803 +/- 0.088, 0.426 +/- 0.136 ng TsF/mg extractable protein for the regional lymph nodes, spleen and uterus, respectively, during Day 5 of pregnancy. When implantation was prevented by ovariectomy on Day 4 followed by treatment with only progesterone, amounts of TsF (as a % of Day 5 value) were decreased to 57% in the uterus and increased to 141% in the spleen and 180% in the regional lymph nodes. When implantation was then initiated with the addition of oestradiol-17 beta to the progesterone treatment, amounts of TsF were increased to 206% in the uterus, 318% in the spleen, and remained unchanged at 180% in the regional lymph nodes. These experiments suggest that the amounts of TsF in the uterus and spleen are dependent upon the implantation process, whereas amounts of TsF in the regional lymph nodes are independent of this event.

UI	MeSH Term	Description	Entries
D008198	Lymph Nodes	They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.	Lymph Node,Node, Lymph,Nodes, Lymph
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D010052	Ovariectomy	The surgical removal of one or both ovaries.	Castration, Female,Oophorectomy,Bilateral Ovariectomy,Bilateral Ovariectomies,Castrations, Female,Female Castration,Female Castrations,Oophorectomies,Ovariectomies,Ovariectomies, Bilateral,Ovariectomy, Bilateral
D010064	Embryo Implantation	Endometrial implantation of EMBRYO, MAMMALIAN at the BLASTOCYST stage.	Blastocyst Implantation,Decidual Cell Reaction,Implantation, Blastocyst,Nidation,Ovum Implantation,Blastocyst Implantations,Decidual Cell Reactions,Embryo Implantations,Implantation, Embryo,Implantation, Ovum,Implantations, Blastocyst,Implantations, Embryo,Implantations, Ovum,Nidations,Ovum Implantations
D010065	Embryo Implantation, Delayed	Delay in the attachment and implantation of BLASTOCYST to the uterine ENDOMETRIUM. The blastocyst remains unattached beyond the normal duration thus delaying embryonic development.	Blastocyst Implantation, Delayed,Delayed Embryo Implantation,Implantation, Ovum, Delayed,Nidation, Delayed,Ovum Implantation, Delayed,Blastocyst Implantation Inhibition,Blastocyst Implantation Suppression,Embryo Implantation Inhibition,Embryo Implantation Suppression,Blastocyst Implantations, Delayed,Delayed Blastocyst Implantation,Delayed Blastocyst Implantations,Delayed Embryo Implantations,Delayed Nidation,Delayed Nidations,Delayed Ovum Implantation,Delayed Ovum Implantations,Embryo Implantations, Delayed,Implantation Inhibition, Blastocyst,Implantation Suppression, Blastocyst,Implantation Suppression, Embryo,Nidations, Delayed,Ovum Implantations, Delayed
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011374	Progesterone	The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.	Pregnenedione,Progesterone, (13 alpha,17 alpha)-(+-)-Isomer,Progesterone, (17 alpha)-Isomer,Progesterone, (9 beta,10 alpha)-Isomer
D004958	Estradiol	The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.	17 beta-Estradiol,Estradiol-17 beta,Oestradiol,17 beta-Oestradiol,Aerodiol,Delestrogen,Estrace,Estraderm TTS,Estradiol Anhydrous,Estradiol Hemihydrate,Estradiol Hemihydrate, (17 alpha)-Isomer,Estradiol Monohydrate,Estradiol Valerate,Estradiol Valeriante,Estradiol, (+-)-Isomer,Estradiol, (-)-Isomer,Estradiol, (16 alpha,17 alpha)-Isomer,Estradiol, (16 alpha,17 beta)-Isomer,Estradiol, (17-alpha)-Isomer,Estradiol, (8 alpha,17 beta)-(+-)-Isomer,Estradiol, (8 alpha,17 beta)-Isomer,Estradiol, (9 beta,17 alpha)-Isomer,Estradiol, (9 beta,17 beta)-Isomer,Estradiol, Monosodium Salt,Estradiol, Sodium Salt,Estradiol-17 alpha,Estradiol-17beta,Ovocyclin,Progynon-Depot,Progynova,Vivelle,17 beta Estradiol,17 beta Oestradiol,Estradiol 17 alpha,Estradiol 17 beta,Estradiol 17beta,Progynon Depot
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia