Biomaterial Database

Estimates of daily di-isodecyl phthalate (DIDP) intake calculated from urinary biomonitoring data. 2013

Kevin M Kransler, and Ammie N Bachman, and Richard H McKee

ExxonMobil Biomedical Sciences, Inc., 1545 Route 22 East, Annandale, NJ 08801, USA. kevin.kransler@exxonmobil.com

Biomonitoring of chemical species in biologic media can be a valuable tool in risk assessment since it informs directly on aggregate exposures. While advances in the analytical techniques required for biomonitoring have resulted in increased sensitivity for the detection of chemical species, the detection of a chemical substance in a biological medium (such as blood, urine or breast milk) does not mean that the chemical causes or is associated with an adverse health outcome. In this paper, intake estimates for di-isodecyl phthalate (DIDP), a high molecular weight general purpose plasticizer, were calculated from urinary biomonitoring data representing various population segments and geographic locales. From these data, intake estimates converge on a mean that is <1 μg/kg/day (95th% < 5 μg/kg/day). This intake estimate is at least two orders of magnitude lower than the health-based exposure guidance values (38-150 μg/kg/day) which have been proposed by regulatory authorities and other authoritative bodies as safe exposure levels.

UI	MeSH Term	Description	Entries
D010795	Phthalic Acids	A group of compounds that has the general structure of a dicarboxylic acid-substituted benzene ring. The ortho-isomer is used in dye manufacture. (Dorland, 28th ed)	Acids, Phthalic
D010968	Plasticizers	Materials incorporated mechanically in plastics (usually PVC) to increase flexibility, workability or distensibility; due to the non-chemical inclusion, plasticizers leach out from the plastic and are found in body fluids and the general environment.	Plasticizer
D004781	Environmental Exposure	The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.	Exposure, Environmental,Environmental Exposures,Exposures, Environmental
D004784	Environmental Monitoring	The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.	Monitoring, Environmental,Environmental Surveillance,Surveillance, Environmental
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D017408	Guidelines as Topic	Works about a systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.	Guidelines as Topics
D018570	Risk Assessment	The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)	Assessment, Risk,Benefit-Risk Assessment,Risk Analysis,Risk-Benefit Assessment,Health Risk Assessment,Risks and Benefits,Analysis, Risk,Assessment, Benefit-Risk,Assessment, Health Risk,Assessment, Risk-Benefit,Benefit Risk Assessment,Benefit-Risk Assessments,Benefits and Risks,Health Risk Assessments,Risk Analyses,Risk Assessment, Health,Risk Assessments,Risk Benefit Assessment,Risk-Benefit Assessments