Biomaterial Database

Study of the release process of drugs: suppositories of paracetamol. 1990

J Lauroba, and I Diez, and M Rius, and C Peraire, and J Domenech

Department of Pharmacy, University of Barcelona, Spain.

The release process of paracetamol, formulated in suppositories, prepared with four different Suppocire masses (AM, AML, AS2X and AP), having different hydrophilia, supplied by Gattefossé, was investigated. The release study of paracetamol was carried out "in vitro" by means of the Dissotest apparatus (Sotax), built on the base of the flow-through method. The assay conditions were: pH 7.4 and flow rate of 20 ml/min. The release process was evaluated using the following amodelistic parameters: the mean dissolution time (MDT), the variance of dissolution time (VDT), the dissolution efficiency (DE) and the maximum amount dissolved determined experimentally (Qmax). The amodelistic parameters, after their statistical analysis by the Kruskal-Wallis test, followed by the comparison between data pairs by the Mann-Whitney "U" test, proved that there are significant differences (p less than 0.05), with the exception of Qmax, between the four masses tested. This study shows that the masses which have a surfactant in their composition (AS2X and AP) offer a better release of paracetamol than those which have no surfactant (AM and AML).

UI	MeSH Term	Description	Entries
D000082	Acetaminophen	Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.	Acetamidophenol,Hydroxyacetanilide,Paracetamol,APAP,Acamol,Acephen,Acetaco,Acetominophen,Algotropyl,Anacin-3,Datril,N-(4-Hydroxyphenyl)acetanilide,N-Acetyl-p-aminophenol,Panadol,Tylenol,p-Acetamidophenol,p-Hydroxyacetanilide,Anacin 3,Anacin3
D013488	Suppositories	Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.	Rectal Suppositories,Vaginal Suppositories,Vaginal Suppository,Suppositories, Rectal,Suppositories, Vaginal,Suppository, Vaginal
D015195	Drug Design	The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include PHARMACOKINETICS, dosage analysis, or drug administration analysis.	Computer-Aided Drug Design,Computerized Drug Design,Drug Modeling,Pharmaceutical Design,Computer Aided Drug Design,Computer-Aided Drug Designs,Computerized Drug Designs,Design, Pharmaceutical,Drug Design, Computer-Aided,Drug Design, Computerized,Drug Designs,Drug Modelings,Pharmaceutical Designs
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In