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1. Renin-associated, chronic psychosocial hypertension of 150-160 mmHg develops in groups of mice interacting socially in complex population cages. 2. The blood pressures of 16 males in a cage were measured and an intraperitoneal injection of the angiotensin coverting enzyme inhibitor captopril (SQ 14,225) was given. Three hours later blood pressures were measured again. 3. During the first 3 weeks of psychosocial hypertension SQ 14,225 was without effect. But at 1 month and subsequently up to 7 months, SQ 14,225 reduced blood pressure to the normal range of 120-130 mmHg. 4. Plasma renin activities were not related to the extent of blood pressure reduction by SQ 14,225. Hence other factors in addition to the renin-angiotensin mechanism play a part in maintaining chronic psychosocial hypertension.
J P Henry, and
A J Vander, and
P M Stephens
January 1983,
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J P Henry, and
A J Vander, and
P M Stephens
August 1978,
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J P Henry, and
A J Vander, and
P M Stephens
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J P Henry, and
A J Vander, and
P M Stephens
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J P Henry, and
A J Vander, and
P M Stephens
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J P Henry, and
A J Vander, and
P M Stephens
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J P Henry, and
A J Vander, and
P M Stephens
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Nihon Jinzo Gakkai shi,
J P Henry, and
A J Vander, and
P M Stephens
May 1981,
British journal of clinical pharmacology,
J P Henry, and
A J Vander, and
P M Stephens
January 2016,
European journal of pharmacology,
J P Henry, and
A J Vander, and
P M Stephens
January 1986,
Archivos del Instituto de Cardiologia de Mexico,
