Bioanalytical and instrumental analysis of estrogenic activities in drinking water sources from Yangtze River Delta. 2013

Xinxin Hu, and Wei Shi, and Fu Cao, and Guanjiu Hu, and Yingqun Hao, and Si Wei, and Xinru Wang, and Hongxia Yu
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, People's Republic of China.

The estrogenic activities of source water from Yangtze River, Huaihe River, Taihu Lake and groundwater in Yangtze River Delta in the dry and wet season were determined by use of reporter gene assays based on African green monkey kidney (CV-1) cell lines. Higher estrogenic activities were observed in the dry season, and the estrogenic potentials in water samples from Taihu Lake were greater than other river basins. None of the samples from groundwater showed estrogen receptor (ER) agonist activity. The 17β-Estradiol (E2) equivalents (EEQs) of water samples in the dry season ranged from 9.41×10(-1) to 1.20×10(1) ng E2 L(-1). In the wet season, EEQs of all the water samples were below the detection limit as 9.00×10(-1) ng E2 L(-1) except for one sample from Huaihe River. The highest contribution of E2 was detected in Yangtze River as 99% of estrogenic activity. Nonylphenol (NP, 100% detection rate) and octylphenol (OP, 100% detection rate) might also be responsible for the estrogenic activities in water sources. Potential health risk induced by the estrogenic chemicals in source water may be posed to the residents through water drinking.

UI MeSH Term Description Entries
D004784 Environmental Monitoring The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment. Monitoring, Environmental,Environmental Surveillance,Surveillance, Environmental
D004967 Estrogens Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds. Estrogen,Estrogen Effect,Estrogen Effects,Estrogen Receptor Agonists,Estrogenic Agents,Estrogenic Compounds,Estrogenic Effect,Estrogenic Effects,Agents, Estrogenic,Agonists, Estrogen Receptor,Compounds, Estrogenic,Effects, Estrogen,Effects, Estrogenic,Receptor Agonists, Estrogen
D014874 Water Pollutants, Chemical Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water. Chemical Water Pollutants,Landfill Leachate,Leachate, Landfill,Pollutants, Chemical Water
D014877 Water Pollution, Chemical Adverse effect upon bodies of water (LAKES; RIVERS; seas; groundwater etc.) caused by CHEMICAL WATER POLLUTANTS. Chemical Water Pollution,Chemical Water Pollutions,Pollution, Chemical Water,Pollutions, Chemical Water,Water Pollutions, Chemical
D014881 Water Supply Means or process of supplying water (as for a community) usually including reservoirs, tunnels, and pipelines and often the watershed from which the water is ultimately drawn. (Webster, 3d ed) Supplies, Water,Supply, Water,Water Supplies
D045483 Rivers Large natural streams of FRESH WATER formed by converging tributaries and which empty into a body of water (lake or ocean). Streams,River,Stream
D052244 Endocrine Disruptors Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism. Endocrine Disrupting Chemical,Endocrine Disrupting Chemicals,Endocrine Disruptor,Endocrine Disruptor Effect,Endocrine Disruptor Effects,Chemical, Endocrine Disrupting,Chemicals, Endocrine Disrupting,Disrupting Chemical, Endocrine,Disruptor Effect, Endocrine,Disruptor Effects, Endocrine,Disruptor, Endocrine,Disruptors, Endocrine,Effect, Endocrine Disruptor,Effects, Endocrine Disruptor
D060587 Groundwater Liquid water present beneath the surface of the earth. Aquifers,Ground Water,Ground-Water,Subterranean Lakes,Underground Lakes,Underground Streams,Underground Water,Water Table,Aquifer,Ground Waters,Ground-Waters,Groundwaters,Lake, Subterranean,Lake, Underground,Lakes, Subterranean,Lakes, Underground,Stream, Underground,Streams, Underground,Subterranean Lake,Table, Water,Tables, Water,Underground Lake,Underground Stream,Underground Waters,Water Tables,Water, Underground,Waters, Underground
D060766 Drinking Water Water that is intended to be ingested. Bottled Water,Potable Water,Water, Bottled,Water, Drinking,Water, Potable

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