OBJECTIVE Aloe species have been noted to be a miracle cure used by indigenous people of southern Africa. Geographically, each of the three Aloe species-Aloe arborescens, Aloe excelsa, and Aloe ferox-has a specific habitat. Although some species overlap in geographical regions, the species most abundant in a region is most often utilized by indigenous people. All three species display similar curative properties, aiding in wound healing, cures against other skin ailments, and some systemic conditions. RESULTS All three Aloe species indicated high inhibitory activity against all gram-positive bacteria under investigation. The ethanol extract was most effective and inhibited all gram-positive bacteria and two gram-negative bacteria (i.e., Proteus vulgaris and Escherichia coli). CONCLUSIONS All fungal species under investigation were successfully inhibited by both the boiled water as well as the ethanol extract, substantiating the traditional usage of this species.