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MOPC-460 mouse plasmacytoma cells produce intracellular A-type particles and extracellular oncornavirus-like particles ("myeloma-associated virus," abbreviated MAV). The genomes of these two particles are closely related. During attempts to establish infections with MOPC-460 extracellular particles, we isolated ecotropic and xenotropic infectious forms of murine leukemia virus. We have investigated the relation of these isolates to A-type particles and to MAV by nucleic acid hybridization. Using complementary DNA probes prepared from the two isolates, we found that these infectious murine leukemia viruses differ from A-type particles and from MAV. Moreover, we found that MAV is the predominant extracellular component: the ecotropic and xenotropic forms of murine leukemia virus were present at only low levels (less than 5%) in MAV preparations. Neither the SC-1 cells infected with ectropic murine leukemia virus nor the mink cells infected with xenotropic murine leukemia virus showed any A-type particles in their cytoplasm when examined by electron microscopy. Our inability to demonstrate infection by the A-type particle-related component, MAV, suggests that these may be defective.
T V Ramabhadran, and
J W Hartley, and
W P Rowe, and
T Godefroy-Colburn, and
P S Jhabvala, and
R E Thach
October 1979,
Journal of virology,
T V Ramabhadran, and
J W Hartley, and
W P Rowe, and
T Godefroy-Colburn, and
P S Jhabvala, and
R E Thach
April 1976,
Journal of virology,
T V Ramabhadran, and
J W Hartley, and
W P Rowe, and
T Godefroy-Colburn, and
P S Jhabvala, and
R E Thach
January 1974,
Biochemistry,
T V Ramabhadran, and
J W Hartley, and
W P Rowe, and
T Godefroy-Colburn, and
P S Jhabvala, and
R E Thach
September 1978,
Cancer research,
T V Ramabhadran, and
J W Hartley, and
W P Rowe, and
T Godefroy-Colburn, and
P S Jhabvala, and
R E Thach
November 1973,
International journal of cancer,
T V Ramabhadran, and
J W Hartley, and
W P Rowe, and
T Godefroy-Colburn, and
P S Jhabvala, and
R E Thach
January 1989,
Cancer immunology, immunotherapy : CII,
T V Ramabhadran, and
J W Hartley, and
W P Rowe, and
T Godefroy-Colburn, and
P S Jhabvala, and
R E Thach
February 1977,
Archives of neurology,
T V Ramabhadran, and
J W Hartley, and
W P Rowe, and
T Godefroy-Colburn, and
P S Jhabvala, and
R E Thach
November 1984,
Cancer research,
T V Ramabhadran, and
J W Hartley, and
W P Rowe, and
T Godefroy-Colburn, and
P S Jhabvala, and
R E Thach
January 1979,
Annales d'immunologie,
T V Ramabhadran, and
J W Hartley, and
W P Rowe, and
T Godefroy-Colburn, and
P S Jhabvala, and
R E Thach
January 1974,
Neoplasma,
