Biomaterial Database

Nonsteroidal anti-inflammatory drugs and coma: a case report of fenoprofen overdose. 1990

J M Kolodzik, and M A Eilers, and M G Angelos

Department of Emergency Medicine, Wright State University, School of Medicine, Dayton, Ohio 45401-0927.

We present the case of a 17-year-old girl who ingested 24 to 36 g fenoprofen as a suicidal gesture. She presented with coma, hypotension, metabolic acidosis, and respiratory depression within four hours of ingestion. The most common adverse effects of the nonsteroidal anti-inflammatory drugs occur in both therapeutic and toxic doses and include gastrointestinal upset, blood dyscrasias, and analgesic nephropathy. The propionic acid derivatives of nonsteroidal anti-inflammatory drugs, including fenoprofen and ibuprofen, are rarely associated with severe toxic effects. This is the first report of pure fenoprofen overdose presenting as coma and metabolic acidosis.

UI	MeSH Term	Description	Entries
D010666	Phenylpropionates	Derivatives of 3-phenylpropionic acid, including its salts and esters.
D003128	Coma	A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.	Comatose,Pseudocoma,Comas,Pseudocomas
D004630	Emergencies	Situations or conditions requiring immediate intervention to avoid serious adverse results.	Emergency
D005260	Female		Females
D005279	Fenoprofen	A propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.	Fenoprofen Calcium,Fenoprofen Dihydrate, Calcium Salt,Fenoprofen, Anhydrous, Calcium Salt,Nalfon,Nalgesic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000138	Acidosis	A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.	Metabolic Acidosis,Acidoses,Acidoses, Metabolic,Acidosis, Metabolic,Metabolic Acidoses
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D013406	Suicide, Attempted	The unsuccessful attempt to kill oneself.	Parasuicide,Suicide Attempt,Attempt, Suicide,Attempted Suicide,Parasuicides
D062787	Drug Overdose	Accidental or deliberate use of a medication or street drug in excess of normal dosage.	Drug Overdoses,Overdose, Drug,Overdoses, Drug