Biomaterial Database

The floccular syndrome in herpes simplex type 1 encephalitis. 2013

Aasef G Shaikh, and Pichet Termsarasab, and David E Riley, and Bashar Katirji

Department of Neurology, Case Western Reserve University, Cleveland, OH, United States. aasefshaikh@gmail.com

A woman with herpes simplex virus type 1 (HSV1) encephalitis had downbeat nystagmus. The nystagmus was robust in primary gaze but attenuated during upgaze, suggestive of the flocculus involvement. FLAIR and T2-sequences of the brain MRI revealed cerebral lesions typical of HSV1, but also patchy hyperintensities in bilateral flocculi. Cerebrospinal fluid polymerase chain reaction confirmed HSV1 infection. Encephalopathy and downbeat nystagmus gradually improved with acyclovir therapy.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009759	Nystagmus, Pathologic	Involuntary movements of the eye that are divided into two types, jerk and pendular. Jerk nystagmus has a slow phase in one direction followed by a corrective fast phase in the opposite direction, and is usually caused by central or peripheral vestibular dysfunction. Pendular nystagmus features oscillations that are of equal velocity in both directions and this condition is often associated with visual loss early in life. (Adams et al., Principles of Neurology, 6th ed, p272)	Convergence Nystagmus,Horizontal Nystagmus,Jerk Nystagmus,Pendular Nystagmus,Periodic Alternating Nystagmus,Rotary Nystagmus,See-Saw Nystagmus,Vertical Nystagmus,Conjugate Nystagmus,Dissociated Nystagmus,Fatigable Positional Nystagmus,Multidirectional Nystagmus,Non-Fatigable Positional Nystagmus,Permanent Nystagmus,Rebound Nystagmus,Retraction Nystagmus,Rotational Nystagmus,Spontaneous Ocular Nystagmus,Symptomatic Nystagmus,Temporary Nystagmus,Unidirectional Nystagmus,Non Fatigable Positional Nystagmus,Nystagmus, Conjugate,Nystagmus, Convergence,Nystagmus, Dissociated,Nystagmus, Fatigable Positional,Nystagmus, Horizontal,Nystagmus, Jerk,Nystagmus, Multidirectional,Nystagmus, Non-Fatigable Positional,Nystagmus, Pendular,Nystagmus, Periodic Alternating,Nystagmus, Permanent,Nystagmus, Rebound,Nystagmus, Retraction,Nystagmus, Rotary,Nystagmus, Rotational,Nystagmus, See-Saw,Nystagmus, Spontaneous Ocular,Nystagmus, Symptomatic,Nystagmus, Temporary,Nystagmus, Unidirectional,Nystagmus, Vertical,Ocular Nystagmus, Spontaneous,Pathologic Nystagmus,Positional Nystagmus, Non-Fatigable,See Saw Nystagmus
D005260	Female		Females
D006561	Herpes Simplex	A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	Herpes Simplex Virus Infection
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D018259	Herpesvirus 1, Human	The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions.	HSV-1,Herpes Simplex Virus 1,HHV-1,Herpes Simplex Virus Type 1,Herpesvirus 1 (alpha), Human,Human Herpesvirus 1
D020803	Encephalitis, Herpes Simplex	An acute (or rarely chronic) inflammatory process of the brain caused by SIMPLEXVIRUS infections which may be fatal. The majority of infections are caused by human herpesvirus 1 (HERPESVIRUS 1, HUMAN) and less often by human herpesvirus 2 (HERPESVIRUS 2, HUMAN). Clinical manifestations include FEVER; HEADACHE; SEIZURES; HALLUCINATIONS; behavioral alterations; APHASIA; hemiparesis; and COMA. Pathologically, the condition is marked by a hemorrhagic necrosis involving the medial and inferior TEMPORAL LOBE and orbital regions of the FRONTAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, pp751-4)	Herpes Simplex Encephalitis,Herpetic Acute Necrotizing Encephalitis,Meningoencephalitis, Herpes Simplex Virus,Acute Necrotizing Encephalitis, Herpetic,Herpes Encephalitis,Herpes Simplex Meningoencephalitis,Herpetic Encephalitis,Herpetic Meningoencephalitis,Encephalitides, Herpes Simplex,Encephalitides, Herpetic,Encephalitis, Herpes,Encephalitis, Herpetic,Herpes Simplex Encephalitides,Herpes Simplex Meningoencephalitides,Herpetic Encephalitides,Herpetic Meningoencephalitides,Meningoencephalitides, Herpes Simplex,Meningoencephalitides, Herpetic,Meningoencephalitis, Herpes Simplex,Meningoencephalitis, Herpetic