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Human CD27+IgM+IgD+ B cells: T-cell or TLR-dependent? 2012

Menno C van Zelm
Erasmus MC.

In this issue of Blood,Weller et al studied patients with rare immunodeficiencies to demonstrate a role for Toll-like receptors (TLRs) in homeostasis of human CD27+IgM+IgD+B cells.

UI MeSH Term Description Entries
D007072 Immunoglobulin D An immunoglobulin which accounts for less than 1% of plasma immunoglobulin. It is found on the membrane of many circulating B LYMPHOCYTES. IgD,IgD1,IgD2
D007075 Immunoglobulin M A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin. Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D008562 Membrane Glycoproteins Glycoproteins found on the membrane or surface of cells. Cell Surface Glycoproteins,Surface Glycoproteins,Cell Surface Glycoprotein,Membrane Glycoprotein,Surface Glycoprotein,Glycoprotein, Cell Surface,Glycoprotein, Membrane,Glycoprotein, Surface,Glycoproteins, Cell Surface,Glycoproteins, Membrane,Glycoproteins, Surface,Surface Glycoprotein, Cell,Surface Glycoproteins, Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001402 B-Lymphocytes Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent
D017472 Receptors, Interleukin-1 Cell surface receptors that are specific for INTERLEUKIN-1. Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. Signaling from interleukin-1 receptors occurs via interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88. IL-1 Receptor,IL-1 Receptors,IL1 Receptor,Interleukin-1 Receptor,Interleukin-1 Receptors,Receptor, Interleukin-1,Receptors, IL-1,IL1 Receptors,Interleukin 1 Receptor,IL 1 Receptor,IL 1 Receptors,Interleukin 1 Receptors,Receptor, IL-1,Receptor, IL1,Receptor, Interleukin 1,Receptors, IL 1,Receptors, IL1,Receptors, Interleukin 1
D053592 Interleukin-1 Receptor-Associated Kinases A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. Signaling from these kinases involves their interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88 and TNF RECEPTOR-ASSOCIATED FACTOR 6. IL-1 Receptor-Associated Kinase,IRAK Kinases,IRAK-1 Kinase,IRAK-2 Kinase,IRAK-3 Kinase,IRAK-4 Kinase,Interleukin-1 Receptor-Associated Kinase,Interleukin-1 Receptor-Associated Kinase 1,Interleukin-1 Receptor-Associated Kinase 2,Interleukin-1 Receptor-Associated Kinase 3,Interleukin-1 Receptor-Associated Kinase 4,IL 1 Receptor Associated Kinase,IRAK 1 Kinase,IRAK 2 Kinase,IRAK 3 Kinase,IRAK 4 Kinase,Interleukin 1 Receptor Associated Kinase,Interleukin 1 Receptor Associated Kinase 1,Interleukin 1 Receptor Associated Kinase 2,Interleukin 1 Receptor Associated Kinase 3,Interleukin 1 Receptor Associated Kinase 4,Interleukin 1 Receptor Associated Kinases,Kinase, IL-1 Receptor-Associated,Kinase, IRAK-1,Kinase, IRAK-2,Kinase, IRAK-3,Kinase, IRAK-4,Kinase, Interleukin-1 Receptor-Associated,Kinases, IRAK,Kinases, Interleukin-1 Receptor-Associated,Receptor-Associated Kinase, IL-1,Receptor-Associated Kinase, Interleukin-1,Receptor-Associated Kinases, Interleukin-1
D053594 Myeloid Differentiation Factor 88 An intracellular signaling adaptor protein that plays a role in TOLL-LIKE RECEPTOR and INTERLEUKIN 1 RECEPTORS signal transduction. It forms a signaling complex with the activated cell surface receptors and members of the IRAK KINASES. MyD88 Protein,TLR Signal Adaptor Protein MyD88,Toll-Like Receptor Signal Adaptor Protein MyD88,Toll Like Receptor Signal Adaptor Protein MyD88
D018127 Tumor Necrosis Factor Receptor Superfamily, Member 7 A member of the tumor necrosis factor receptor superfamily found on most T-LYMPHOCYTES. Activation of the receptor by CD70 ANTIGEN results in the increased proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS. Antigens, CD27,CD27 Antigens,T-Cell Activation Antigen,Antigen, CD27,TNFRSF7 Receptor,Activation Antigen, T-Cell,Antigen, T-Cell Activation,CD27 Antigen,Receptor, TNFRSF7,T Cell Activation Antigen
D026901 Membrane Transport Proteins Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS. Biological Pump,Membrane Transport Protein,Membrane Transporter,Membrane Transporters,Metabolic Pump,Permease,Biological Pumps,Metabolic Pumps,Permeases,Pump, Biologic,Pump, Biological,Pump, Metabolic,Pumps, Biological,Pumps, Metabolic,Biologic Pump,Protein, Membrane Transport,Transport Protein, Membrane,Transport Proteins, Membrane,Transporter, Membrane,Transporters, Membrane

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