The response to adverse environmental factors, manifesting itself in the reduction of bodily reserves, deterioration of adaptive state and immune status is an integrated indicator used for measuring these adverse effects. A study of the dependence of autonomic balance on gender, age and environmental risks factors has revealed a pronounced sympathicotonia among 64.4-91.5% children and stress of regulatory system among 60.5% cases. The activity of sympathetic nervous system increases with age, especially among men. The severity of disorders depends on the level of emotional stress. The study has found a connection between the general non-specific adaptive response of tumors and cardiovascular diseases.