Edwards SAPIEN and Edwards SAPIEN XT transcatheter heart valves for the treatment of severe aortic stenosis. 2012

Melanie Freeman, and John G Webb
St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.

Aortic stenosis is the most common heart valve lesion, with aortic valve replacement being the most common type of valve surgery in the Western world. With the aging population, more and more patients are declined for surgical aortic valve replacement owing to age and comorbidities. Without intervention, morbidity is significant and early mortality inevitable. Transcatheter aortic valve replacement is an exciting technology offering an alternative, less invasive treatment in those not eligible for surgery. The Edwards SAPIEN and Edwards SAPIEN XT transcatheter heart valves are currently in widespread use, with promising outcomes in terms of short-to-medium-term mortality and valve durability in high-risk patients or patients not eligible for surgical valve replacement. Randomized trials are currently underway to assess transcatheter aortic valve replacement in lower risk surgical candidates, while long-term mortality data are keenly awaited.

UI MeSH Term Description Entries
D006328 Cardiac Catheterization Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures. Catheterization, Cardiac,Catheterization, Heart,Heart Catheterization,Cardiac Catheterizations,Catheterizations, Cardiac,Catheterizations, Heart,Heart Catheterizations
D006350 Heart Valve Prosthesis A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material. Prosthesis, Heart Valve,Cardiac Valve Prosthesis,Cardiac Valve Prostheses,Heart Valve Prostheses,Prostheses, Cardiac Valve,Prostheses, Heart Valve,Prosthesis, Cardiac Valve,Valve Prostheses, Cardiac,Valve Prostheses, Heart,Valve Prosthesis, Cardiac,Valve Prosthesis, Heart
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001021 Aortic Valve The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle. Aortic Valves,Valve, Aortic,Valves, Aortic
D001024 Aortic Valve Stenosis A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA. Aortic Stenosis,Aortic Valve Stenoses,Stenoses, Aortic,Stenoses, Aortic Valve,Stenosis, Aortic,Stenosis, Aortic Valve,Valve Stenoses, Aortic,Valve Stenosis, Aortic
D019918 Heart Valve Prosthesis Implantation Surgical insertion of synthetic material to repair injured or diseased heart valves. Implantation, Heart Valve Prosthesis
D040541 Marketing Activity involved in transfer of goods from producer to consumer or in the exchange of services. Audience Research,Market Research,Research, Audience,Research, Market

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