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Anti-glomerular basement membrane glomerulonephritis complicated by thrombocytopenia. 2012
Takuya Miki, and
Tetsu Akimoto, and
Taro Sugase, and
Akihiko Numata, and
Naoko Otani, and
Yoshitaka Iwazu, and
Eri Takeshima, and
Yoshiyuki Morishita, and
Shigeaki Muto, and
Eiji Kusano
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
Rapidly progressive glomerulonephritis (RPGN) is characterized by the rapid deterioration of the renal function associated with crescent formation on renal biopsies. This report describes a case of RPGN caused by anti-glomerular basement membrane (GBM) glomerulonephritis in an elderly man with severe thrombocytopenia and a platelet count of 1.4 × 10(4)/µL. Thrombotic microangiopathy (TMA) and heparin-induced thrombocytopenia (HIT) were implicated in the severe decrease in platelets. This report also discusses the pathological background and clinical management of TMA and HIT among patients with anti-GBM glomerulonephritis.
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