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The clinical characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis. 2012
Kei Kunimasa, and
Machiko Arita, and
Takashi Nakazawa, and
Maki Tanaka, and
Kazuya Tsubouchi, and
Satoshi Konishi, and
Yasushi Fukuda, and
Mika Saigusa, and
Hiroaki Nakagawa, and
Satoshi Ubukata, and
Yohei Korogi, and
Takao Fujii, and
Tsuneyo Mimori, and
Tadashi Ishida
Department of Respiratory Medicine, Kurashiki Central Hospital, Japan. keikunimasa@gmail.com
We herein report the clinical and laboratory characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis (PM/DM). We compared these characteristics with previously published findings. Previous reports and our present cases show that anti-OJ autoantibody-positive interstitial lung disease (ILD) patients with PM/DM lack the manifestations of Raynaud's phenomenon and sclerodactyly and show good prognoses and responses to glucocorticoid therapy. These results indicate that the presence of anti-OJ autoantibodies may be useful for predicting the prognosis of ILD and its clinical course in PM/DM patients.
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