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1. The toxicokinetics of paraquat were studied in 18 cases of acute human poisoning using a specific radioimmunoassay. Plasma paraquat concentration exhibited a mean distribution half-life (t1/2 alpha) of 5 h and a mean elimination half-life (t1/2 beta) of 84 h. Cardiovascular collapse supervened early during the course of the intoxication and was associated with the distribution phase. Death related to pulmonary fibrosis occurred late and was associated with the elimination phase. 2. Pharmacokinetic analysis of urine paraquat excretion confirmed the biphasic decline of paraquat. Moreover, renal paraquat and creatinine clearances were not correlated but renal paraquat clearance was never higher than the renal creatinine clearance. 3. Tissue paraquat distribution was ubiquitous with an apparent volume of distribution ranging from 1.2 to 1.6 l/kg. Muscle could represent an important reservoir explaining the long persistence of paraquat in plasma and urine for several weeks or months after poisoning.
P Houzé, and
F J Baud, and
R Mouy, and
C Bismuth, and
R Bourdon, and
J M Scherrmann
October 2010,
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases,
P Houzé, and
F J Baud, and
R Mouy, and
C Bismuth, and
R Bourdon, and
J M Scherrmann
October 2007,
Environmental health perspectives,
P Houzé, and
F J Baud, and
R Mouy, and
C Bismuth, and
R Bourdon, and
J M Scherrmann
February 2009,
Experimental neurology,
P Houzé, and
F J Baud, and
R Mouy, and
C Bismuth, and
R Bourdon, and
J M Scherrmann
January 2016,
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology,
P Houzé, and
F J Baud, and
R Mouy, and
C Bismuth, and
R Bourdon, and
J M Scherrmann
October 1996,
Toxicology,
P Houzé, and
F J Baud, and
R Mouy, and
C Bismuth, and
R Bourdon, and
J M Scherrmann
June 1988,
Toxicology and industrial health,
P Houzé, and
F J Baud, and
R Mouy, and
C Bismuth, and
R Bourdon, and
J M Scherrmann
September 2022,
The Journal of international medical research,
P Houzé, and
F J Baud, and
R Mouy, and
C Bismuth, and
R Bourdon, and
J M Scherrmann
November 2018,
Wei sheng yan jiu = Journal of hygiene research,
P Houzé, and
F J Baud, and
R Mouy, and
C Bismuth, and
R Bourdon, and
J M Scherrmann
June 1999,
Toxicology and applied pharmacology,
P Houzé, and
F J Baud, and
R Mouy, and
C Bismuth, and
R Bourdon, and
J M Scherrmann
February 1999,
Bulletin of environmental contamination and toxicology,
