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In recent years, there has been a growing interest in anticancer potential of valproic acid (VPA) resulting from inhibition of histone deacetylase activity. The aim of our study was to evaluate the influence of valproic acid and cisplatin (CPT) on the growth rate of human melanoma cell lines: A375 (melanotic) and C32 (amelanotic). Both tested drugs decreased cell proliferation in a dose-dependent manner. VPA used alone significantly inhibited the growth of both cell lines at concentrations of 3 and 10 mM. Cisplatin significantly decreased cell proliferation at concentration = 0.3 microM. However, VPA enhanced the cytostatic action of CPT since simultaneous exposure of cells to 1 mM VPA and 0.1 microM CPT resulted in a significant reduction of cell growth. It can be concluded that VPA increases the sensitivity of melanoma cells to chemotherapeutic agent -- cisplatin.
Ewa Chodurek, and
Arkadiusz Orchel, and
Arkadiusz Gruchlik, and
Ewelina Aleksander, and
Karolina Gołabek, and
Zofia Dzierzewicz
April 2009,
International journal of cancer,
Ewa Chodurek, and
Arkadiusz Orchel, and
Arkadiusz Gruchlik, and
Ewelina Aleksander, and
Karolina Gołabek, and
Zofia Dzierzewicz
December 2012,
Pediatric blood & cancer,
Ewa Chodurek, and
Arkadiusz Orchel, and
Arkadiusz Gruchlik, and
Ewelina Aleksander, and
Karolina Gołabek, and
Zofia Dzierzewicz
November 2020,
International immunopharmacology,
Ewa Chodurek, and
Arkadiusz Orchel, and
Arkadiusz Gruchlik, and
Ewelina Aleksander, and
Karolina Gołabek, and
Zofia Dzierzewicz
March 2012,
Molecules (Basel, Switzerland),
Ewa Chodurek, and
Arkadiusz Orchel, and
Arkadiusz Gruchlik, and
Ewelina Aleksander, and
Karolina Gołabek, and
Zofia Dzierzewicz
June 2008,
Cancer science,
Ewa Chodurek, and
Arkadiusz Orchel, and
Arkadiusz Gruchlik, and
Ewelina Aleksander, and
Karolina Gołabek, and
Zofia Dzierzewicz
December 2009,
Molecular cancer research : MCR,
Ewa Chodurek, and
Arkadiusz Orchel, and
Arkadiusz Gruchlik, and
Ewelina Aleksander, and
Karolina Gołabek, and
Zofia Dzierzewicz
January 2016,
Journal of Cancer,
Ewa Chodurek, and
Arkadiusz Orchel, and
Arkadiusz Gruchlik, and
Ewelina Aleksander, and
Karolina Gołabek, and
Zofia Dzierzewicz
July 2010,
Journal of cellular biochemistry,
Ewa Chodurek, and
Arkadiusz Orchel, and
Arkadiusz Gruchlik, and
Ewelina Aleksander, and
Karolina Gołabek, and
Zofia Dzierzewicz
March 2016,
Oncotarget,
Ewa Chodurek, and
Arkadiusz Orchel, and
Arkadiusz Gruchlik, and
Ewelina Aleksander, and
Karolina Gołabek, and
Zofia Dzierzewicz
May 2024,
Chemical biology & drug design,
