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In 1973 PBB's were accidentally mixed into animal feed, resulting in marked toxic effects. Meat and dairy products were widely consumed in Michigan. To determine the impact of PBB's, 55 exposed Michigan farm residents, 11 Michigan chemical workers and 46 non-exposed Wisconsin farmers were examined. Abnormalities included decreased number of T-lymphocytes with concomitant increase of lymphocytes with no detectable surface markers, "null cells", and altered lymphocyte function. Data obtained from skin testing using standard recall antigens, showed no consistent correlation between the delayed cutaneous hypersensitivity response and the impaired lymphocyte function. PBB (hexa) in separated white blood cells and red cells was positively identified and quantified by gas chromatography-mass spectrometry. PBB and immunological abnormalities were not detected in non-exposed Wisconsin dairy farm residents.
J G Bekesi, and
J Roboz, and
H A Anderson, and
J P Roboz, and
A S Fischbein, and
I J Selikoff, and
J F Holland
March 1978,
Science (New York, N.Y.),
J G Bekesi, and
J Roboz, and
H A Anderson, and
J P Roboz, and
A S Fischbein, and
I J Selikoff, and
J F Holland
April 1978,
Environmental health perspectives,
J G Bekesi, and
J Roboz, and
H A Anderson, and
J P Roboz, and
A S Fischbein, and
I J Selikoff, and
J F Holland
February 1977,
Environmental research,
J G Bekesi, and
J Roboz, and
H A Anderson, and
J P Roboz, and
A S Fischbein, and
I J Selikoff, and
J F Holland
March 1983,
American journal of public health,
J G Bekesi, and
J Roboz, and
H A Anderson, and
J P Roboz, and
A S Fischbein, and
I J Selikoff, and
J F Holland
January 1979,
Veterinary and human toxicology,
J G Bekesi, and
J Roboz, and
H A Anderson, and
J P Roboz, and
A S Fischbein, and
I J Selikoff, and
J F Holland
June 1981,
Science (New York, N.Y.),
J G Bekesi, and
J Roboz, and
H A Anderson, and
J P Roboz, and
A S Fischbein, and
I J Selikoff, and
J F Holland
November 1976,
Journal of toxicology and environmental health,
J G Bekesi, and
J Roboz, and
H A Anderson, and
J P Roboz, and
A S Fischbein, and
I J Selikoff, and
J F Holland
October 1982,
Environmental research,
J G Bekesi, and
J Roboz, and
H A Anderson, and
J P Roboz, and
A S Fischbein, and
I J Selikoff, and
J F Holland
April 1978,
Environmental health perspectives,
J G Bekesi, and
J Roboz, and
H A Anderson, and
J P Roboz, and
A S Fischbein, and
I J Selikoff, and
J F Holland
April 1978,
Environmental health perspectives,
