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There is a close relationship between the rates at which dominant lethal mutations and heritable translocations are induced by ethyl methanesulfonate (EMS) or triethylenemelamine (TEM) in male postmeiotic germ cells. This relationship does not hold for isopropyl methanesulfonate (IMS), which induced only negligible frequencies of heritable translocations at doses that induced high levels of dominant lethal mutations. Nor does IMS behave like EMS and TEM in the degree to which eggs of different stocks of females repair premutational lesions that are carried in the sperm-large differences between stocks for IMS treatment and small differences for EMS or TEM treatment. These dissimilarities between IMS and the other two alkylating chemicals are postulated to be attributable to differences in the types of lesions present at the time of repair activity and to whether or not chromosomal aberrations are already fixed prior to postfertilization pronuclear DNA synthesis.
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K T Cain
May 1982,
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W M Generoso, and
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December 1996,
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W M Generoso, and
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January 1998,
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W M Generoso, and
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January 1985,
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W M Generoso, and
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January 1968,
Mutation research,
W M Generoso, and
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January 1988,
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W M Generoso, and
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January 1990,
Environmental and molecular mutagenesis,
W M Generoso, and
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May 1964,
Heredity,
W M Generoso, and
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October 1985,
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W M Generoso, and
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September 1977,
Archives of toxicology,
