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Von Hippel-Lindau (VHL) disease was initially reported to be linked to the RAF1 oncogene (3p25). We have ascertained and sampled two large multigenerational VHL families for linkage studies, in order to confirm the localization of the VHL gene as a prelude to fine mapping studies. The probes used in the analysis were p627 (RAF1) and pHeA12 (thyroid hormone receptor B) (3p24.1-3p22). VHL was analyzed as an autosomal dominant trait with age-dependent penetrance. The maximum lod score combining both families was z(theta) = 2.16 at theta = 0.0 for RAF1 and z(theta) = 2.20 at theta = 0.05 for thyroid hormone receptor B. Multipoint analysis using the RAF1 and thyroid hormone receptor B loci resulted in a peak lod score of 3.1 confirming linkage of VHL to this region of chromosome 3. However, the position of VHL relative to the two loci could not be established with certainty.
J M Vance, and
K W Small, and
M A Jones, and
J M Stajich, and
L H Yamaoka, and
A D Roses, and
W Y Hung, and
M A Pericak-Vance
January 2018,
Advances in experimental medicine and biology,
J M Vance, and
K W Small, and
M A Jones, and
J M Stajich, and
L H Yamaoka, and
A D Roses, and
W Y Hung, and
M A Pericak-Vance
April 1993,
Bratislavske lekarske listy,
J M Vance, and
K W Small, and
M A Jones, and
J M Stajich, and
L H Yamaoka, and
A D Roses, and
W Y Hung, and
M A Pericak-Vance
June 2003,
Lancet (London, England),
J M Vance, and
K W Small, and
M A Jones, and
J M Stajich, and
L H Yamaoka, and
A D Roses, and
W Y Hung, and
M A Pericak-Vance
November 2005,
Hereditary cancer in clinical practice,
J M Vance, and
K W Small, and
M A Jones, and
J M Stajich, and
L H Yamaoka, and
A D Roses, and
W Y Hung, and
M A Pericak-Vance
November 1997,
Medicine,
J M Vance, and
K W Small, and
M A Jones, and
J M Stajich, and
L H Yamaoka, and
A D Roses, and
W Y Hung, and
M A Pericak-Vance
March 2000,
Harefuah,
J M Vance, and
K W Small, and
M A Jones, and
J M Stajich, and
L H Yamaoka, and
A D Roses, and
W Y Hung, and
M A Pericak-Vance
January 2009,
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti,
J M Vance, and
K W Small, and
M A Jones, and
J M Stajich, and
L H Yamaoka, and
A D Roses, and
W Y Hung, and
M A Pericak-Vance
June 2016,
Journal of pediatric genetics,
J M Vance, and
K W Small, and
M A Jones, and
J M Stajich, and
L H Yamaoka, and
A D Roses, and
W Y Hung, and
M A Pericak-Vance
March 2000,
Mayo Clinic proceedings,
J M Vance, and
K W Small, and
M A Jones, and
J M Stajich, and
L H Yamaoka, and
A D Roses, and
W Y Hung, and
M A Pericak-Vance
September 2006,
Nihon rinsho. Japanese journal of clinical medicine,
