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Discovery of novel 1,4-dihydropyridine-based PDE4 inhibitors. 2013
Rajamohan R Poondra, and
Ratnam V Nallamelli, and
Chandana Lakshmi Teja Meda, and
B N V Srinivas, and
Anushka Grover, and
Jyotsna Muttabathula, and
Sreedhara R Voleti, and
Balasubramanian Sridhar, and
Manojit Pal, and
Kishore V L Parsa
Department of Medicinal Chemistry, Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India. rajamohanreddyp@ilsresearch.org
Substituted 1,4-dihydropyridines were discovered as a novel and potent series of phosphodiesterase 4 (PDE4) inhibitors. Structure-activity relationships within this series have been carried out and studies revealed that the dihydropyridine core, with indole moiety and 3,4-dimethoxybenzyl group, is a potent analogue for PDE4 inhibition. These novel series of compounds were prepared via a 3-component reaction in a single pot. In vitro biological activity, modeling studies and crystallography data are also reported.
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