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Germanium (Ge; atomic number 32, atomic weight 72.6) belongs to IVb group of the Periodic Table and is found as a trace metal in soil, rocks, plants, and animals. It is widely used in industry because of its semiconductive nature. Some biological activities have been shown in Ge derivatives. Recently, patients with persistent renal damage after chronic ingestion of germanium dioxide (GeO2)-containing compounds have been reported in Japan. This study aimed to investigate subacute nephrotoxicity of GeO2 in Lewis male rats. The rats were treated orally with GeO2 for 13 weeks (GeO2 group) and were compared with those treated with GeO2 for only the first 4 weeks (GeO2-4-week group) and with untreated controls. Renal dysfunction was demonstrated by the increased serum creatinine, BUN, and serum phosphate and decreased creatinine clearance. Liver dysfunction was observed as demonstrated by the increased GOT and GPT, and hypoproteinemia by the decreased total protein and albumin in the GeO2 group. However, daily urinary protein excretion or urinalysis did not differ among the groups. Kidney weight and Ge content of tissues were significantly elevated in the GeO2 group. With the light microscope, vacuoles and the depositions of PAS-stained particles, which correspond to electron-microscopic dense granules in the swollen mitochondria, were predominantly observed in distal tubular epithelium in the GeO2 group. Even in the GeO2-4-week group of rats, serum creatinine was increased and the above-mentioned histological abnormalities were observed, but were less intense.
T Sanai, and
N Oochi, and
S Okuda, and
S Osato, and
S Kiyama, and
T Komota, and
K Onoyama, and
M Fujishima
November 1994,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
T Sanai, and
N Oochi, and
S Okuda, and
S Osato, and
S Kiyama, and
T Komota, and
K Onoyama, and
M Fujishima
June 1991,
Biological trace element research,
T Sanai, and
N Oochi, and
S Okuda, and
S Osato, and
S Kiyama, and
T Komota, and
K Onoyama, and
M Fujishima
January 1993,
Acta neuropathologica,
T Sanai, and
N Oochi, and
S Okuda, and
S Osato, and
S Kiyama, and
T Komota, and
K Onoyama, and
M Fujishima
September 2001,
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih,
T Sanai, and
N Oochi, and
S Okuda, and
S Osato, and
S Kiyama, and
T Komota, and
K Onoyama, and
M Fujishima
January 1991,
Renal failure,
T Sanai, and
N Oochi, and
S Okuda, and
S Osato, and
S Kiyama, and
T Komota, and
K Onoyama, and
M Fujishima
January 1988,
Nephron,
T Sanai, and
N Oochi, and
S Okuda, and
S Osato, and
S Kiyama, and
T Komota, and
K Onoyama, and
M Fujishima
August 1996,
The Journal of the American Association of Gynecologic Laparoscopists,
T Sanai, and
N Oochi, and
S Okuda, and
S Osato, and
S Kiyama, and
T Komota, and
K Onoyama, and
M Fujishima
January 1922,
The Journal of experimental medicine,
T Sanai, and
N Oochi, and
S Okuda, and
S Osato, and
S Kiyama, and
T Komota, and
K Onoyama, and
M Fujishima
February 1999,
Toxicology,
T Sanai, and
N Oochi, and
S Okuda, and
S Osato, and
S Kiyama, and
T Komota, and
K Onoyama, and
M Fujishima
March 1922,
The Journal of experimental medicine,
