Biomaterial Database

Development of immunity to ocular chlamydial infection. 1990

H R Taylor

Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University, Baltimore, Maryland.

The development of "natural immunity" to homologous and heterologous ocular challenge with Chlamydia trachomatis was examined in cynomolgus monkeys given primary or secondary inoculations of C. trachomatis serovars B, C, and E. Overall, serovar E gave more severe disease than the other serovars. The amount of disease induced by the 2 serovar B strains examined, TW-5 and HAR-36, varied. In general, animals showed resistance to homologous secondary challenge, which was better characterized by a reduction in the recovery of culturable organisms than by a reduction in clinical disease. However, following initial heterologous challenge, neither resistance nor aggravation of disease was seen. These observations suggest that a trachoma vaccine will have to contain the serovar-specific antigenic determinants for multiple chlamydial serovars.

UI	MeSH Term	Description	Entries
D007110	Immunity, Active	Resistance to a disease agent resulting from the production of specific antibodies by the host, either after exposure to the disease or after vaccination.	Active Immune Response,Active Immune Responses,Active Immunities,Active Immunity,Immune Response, Active,Immune Responses, Active,Immunities, Active,Response, Active Immune,Responses, Active Immune
D008252	Macaca fascicularis	A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.	Burmese Long-Tailed Macaque,Crab-Eating Monkey,Cynomolgus Monkey,M. f. aurea,M. fascicularis,Macaca fascicularis aurea,Monkey, Crab-Eating,Monkey, Cynomolgus,Crab-Eating Macaque,Burmese Long Tailed Macaque,Crab Eating Macaque,Crab Eating Monkey,Crab-Eating Macaques,Crab-Eating Monkeys,Cynomolgus Monkeys,Long-Tailed Macaque, Burmese,Macaque, Burmese Long-Tailed,Macaque, Crab-Eating,Monkey, Crab Eating
D002692	Chlamydia trachomatis	Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.
D005123	Eye	The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.	Eyes
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014141	Trachoma	A chronic infection of the CONJUNCTIVA and CORNEA caused by CHLAMYDIA TRACHOMATIS.	Egyptian Ophthalmia,Ophthalmia, Egyptian,Trachomas