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Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains. 2013
Janny Westdijk, and
Patrick Koedam, and
Mario Barro, and
Benjamin P Steil, and
Nicolas Collin, and
Thomas S Vedvick, and
Wilfried A M Bakker, and
Peter van der Ley, and
Gideon Kersten
Institute for Translational Vaccinology, Antonie van Leeuwenhoeklaan 9, 3720 AL Bilthoven, The Netherlands. janny.westdijk@rivm.nl
Six different adjuvants, each in combination with inactivated polio vaccine (IPV) produced with attenuated Sabin strains (sIPV), were evaluated for their ability to enhance virus neutralizing antibody titres (VNTs) in the rat potency model. The increase of VNTs was on average 3-, 15-, 24-fold with adjuvants after one immunization (serotypes 1, 2, and 3, respectively). Also after a boost immunization the VNTs of adjuvanted sIPV were on average another 7-20-27 times higher than after two inoculations of sIPV without adjuvant. The results indicate that it is feasible to increase the potency of inactivated polio vaccines by using adjuvants.
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