Biomaterial Database

[Does exogenous airflow resistance reduce endogenous airway resistance in healthy persons?]. 1990

H Felkel, and V Smejkal

Výzkumný ústav tuberkulózy a respiracních nemocí, Praha.

The aim of our investigation was to assess whether a preinserted model resistance of a certain magnitude will expand the airways during inspiration and thus reduce the resistance of the airways conceived as the sum of the value of the endogenous airway resistance without obstruction and the value of the exogenous pre-inserted model resistance. The model resistance and resistance of the airways were assessed by means of a whole-body plethysmograph. The airway resistance was evaluated in 10 healthy men during inspiration and expiration, using a dictated breathing pattern. When a model resistance of 0.75 kPa.l-1.s-1 was preinserted during dictated minute ventilation of 30 l.min-1 and an air current of 1 l.s-1 the value of the airway resistance increased markedly, as compared with the same breathing pattern without obstruction. The resistance increment was, however, by 30% lower than the expected value. At the same time the functional residual lung capacity increased.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D010993	Plethysmography, Whole Body	Measurement of the volume of gas in the lungs, including that which is trapped in poorly communicating air spaces. It is of particular use in chronic obstructive pulmonary disease and emphysema. (Segen, Dictionary of Modern Medicine, 1992)	Whole Body Plethysmography,Body Plethysmographies, Whole,Body Plethysmography, Whole,Plethysmographies, Whole Body,Whole Body Plethysmographies
D012123	Pulmonary Ventilation	The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.	Respiratory Airflow,Ventilation Tests,Ventilation, Pulmonary,Expiratory Airflow,Airflow, Expiratory,Airflow, Respiratory,Test, Ventilation,Tests, Ventilation,Ventilation Test
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000403	Airway Resistance	Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.	Airway Resistances,Resistance, Airway,Resistances, Airway