-transparent.png){kind=logo}
Tryptophan inhibits biofilm formation by Pseudomonas aeruginosa. 2013
Kenneth S Brandenburg, and
Karien J Rodriguez, and
Jonathan F McAnulty, and
Christopher J Murphy, and
Nicholas L Abbott, and
Michael J Schurr, and
Charles J Czuprynski
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Biofilm formation by Pseudomonas aeruginosa has been implicated in the pathology of chronic wounds. Both the d and l isoforms of tryptophan inhibited P. aeruginosa biofilm formation on tissue culture plates, with an equimolar ratio of d and l isoforms producing the greatest inhibitory effect. Addition of d-/l-tryptophan to existing biofilms inhibited further biofilm growth and caused partial biofilm disassembly. Tryptophan significantly increased swimming motility, which may be responsible in part for diminished biofilm formation by P. aeruginosa.
Related Publications
Kenneth S Brandenburg, and
Karien J Rodriguez, and
Jonathan F McAnulty, and
Christopher J Murphy, and
Nicholas L Abbott, and
Michael J Schurr, and
Charles J Czuprynski
January 2013,
PloS one,
Kenneth S Brandenburg, and
Karien J Rodriguez, and
Jonathan F McAnulty, and
Christopher J Murphy, and
Nicholas L Abbott, and
Michael J Schurr, and
Charles J Czuprynski
August 2017,
Experimental and therapeutic medicine,
Kenneth S Brandenburg, and
Karien J Rodriguez, and
Jonathan F McAnulty, and
Christopher J Murphy, and
Nicholas L Abbott, and
Michael J Schurr, and
Charles J Czuprynski
March 2014,
Canadian journal of microbiology,
Kenneth S Brandenburg, and
Karien J Rodriguez, and
Jonathan F McAnulty, and
Christopher J Murphy, and
Nicholas L Abbott, and
Michael J Schurr, and
Charles J Czuprynski
August 2019,
Nagoya journal of medical science,
Kenneth S Brandenburg, and
Karien J Rodriguez, and
Jonathan F McAnulty, and
Christopher J Murphy, and
Nicholas L Abbott, and
Michael J Schurr, and
Charles J Czuprynski
February 2018,
MicrobiologyOpen,
Kenneth S Brandenburg, and
Karien J Rodriguez, and
Jonathan F McAnulty, and
Christopher J Murphy, and
Nicholas L Abbott, and
Michael J Schurr, and
Charles J Czuprynski
February 2022,
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine],
Kenneth S Brandenburg, and
Karien J Rodriguez, and
Jonathan F McAnulty, and
Christopher J Murphy, and
Nicholas L Abbott, and
Michael J Schurr, and
Charles J Czuprynski
January 2013,
PloS one,
Kenneth S Brandenburg, and
Karien J Rodriguez, and
Jonathan F McAnulty, and
Christopher J Murphy, and
Nicholas L Abbott, and
Michael J Schurr, and
Charles J Czuprynski
August 2016,
Canadian journal of microbiology,
Kenneth S Brandenburg, and
Karien J Rodriguez, and
Jonathan F McAnulty, and
Christopher J Murphy, and
Nicholas L Abbott, and
Michael J Schurr, and
Charles J Czuprynski
April 2003,
Journal of bacteriology,
Kenneth S Brandenburg, and
Karien J Rodriguez, and
Jonathan F McAnulty, and
Christopher J Murphy, and
Nicholas L Abbott, and
Michael J Schurr, and
Charles J Czuprynski
October 2020,
Applied and environmental microbiology,
