Biomaterial Database

Respiratory tract deposition of ultrafine particles in subjects with obstructive or restrictive lung disease. 1990

P J Anderson, and J D Wilson, and F C Hiller

Division of Pulmonary and Critical Care Medicine, University of Arkansas for Medical Sciences, Little Rock.

To evaluate the effects of lung disease on deposition of inhaled ultrafine particles (less than 0.1 micron diameter), we measured total respiratory tract deposition of nonhygroscopic particles of 0.02 to 0.24 micron in five subjects with obstructive lung disease and three subjects with restrictive lung disease and compared it with that in ten normal subjects. Deposition was measured as concentration difference of five size fractions in inhaled and exhaled air using an electrical aerosol analyzer. The data showed that deposition of these ultrafine particles was increased in subjects with obstructive lung disease when compared with normal subjects, while it was unchanged in subjects with restrictive lung disease. The increase in deposition in the subjects with obstructive lung disease was significant for particle sizes 0.04 to 0.24 micron. Possible mechanisms for increased deposition in airway obstruction include increased transit time of particles, abnormal expiratory collapse of airways due to flow limitation, and flow perturbations resulting from decreased airway caliber.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008171	Lung Diseases	Pathological processes involving any part of the LUNG.	Pulmonary Diseases,Disease, Pulmonary,Diseases, Pulmonary,Pulmonary Disease,Disease, Lung,Diseases, Lung,Lung Disease
D008173	Lung Diseases, Obstructive	Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.	Obstructive Lung Diseases,Obstructive Pulmonary Diseases,Lung Disease, Obstructive,Obstructive Lung Disease,Obstructive Pulmonary Disease,Pulmonary Disease, Obstructive,Pulmonary Diseases, Obstructive
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010316	Particle Size	Relating to the size of solids.	Particle Sizes,Size, Particle,Sizes, Particle
D012123	Pulmonary Ventilation	The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.	Respiratory Airflow,Ventilation Tests,Ventilation, Pulmonary,Expiratory Airflow,Airflow, Expiratory,Airflow, Respiratory,Test, Ventilation,Tests, Ventilation,Ventilation Test
D012129	Respiratory Function Tests	Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.	Lung Function Tests,Pulmonary Function Tests,Function Test, Pulmonary,Function Tests, Pulmonary,Pulmonary Function Test,Test, Pulmonary Function,Tests, Pulmonary Function,Function Test, Lung,Function Test, Respiratory,Function Tests, Lung,Function Tests, Respiratory,Lung Function Test,Respiratory Function Test,Test, Lung Function,Test, Respiratory Function,Tests, Lung Function,Tests, Respiratory Function
D003652	Decanoic Acids	10-carbon saturated monocarboxylic acids.	Capric Acids,Acids, Capric,Acids, Decanoic
D005260	Female		Females