-transparent.png){kind=logo}
24 month longitudinal data in ambulant boys with Duchenne muscular dystrophy. 2013
Elena Stacy Mazzone, and
Marika Pane, and
Maria Pia Sormani, and
Roberta Scalise, and
Angela Berardinelli, and
Sonia Messina, and
Yvan Torrente, and
Adele D'Amico, and
Luca Doglio, and
Emanuela Viggiano, and
Paola D'Ambrosio, and
Filippo Cavallaro, and
Silvia Frosini, and
Luca Bello, and
Serena Bonfiglio, and
Roberto De Sanctis, and
Enrica Rolle, and
Flaviana Bianco, and
Francesca Magri, and
Francesca Rossi, and
Gessica Vasco, and
Gianluca Vita, and
Maria Chiara Motta, and
Maria Alice Donati, and
Michele Sacchini, and
Tiziana Mongini, and
Antonella Pini, and
Roberta Battini, and
Elena Pegoraro, and
Stefano Previtali, and
Sara Napolitano, and
Claudio Bruno, and
Luisa Politano, and
Giacomo Pietro Comi, and
Enrico Bertini, and
Eugenio Mercuri
Department of Paediatric Neurology, Catholic University, Rome, Italy.
OBJECTIVE The aim of the study was i) to assess the spectrum of changes over 24 months in ambulant boys affected by Duchenne muscular dystrophy, ii) to establish the difference between the first and the second year results and iii) to identify possible early markers of loss of ambulation. METHODS One hundred and thirteen patients (age range 4.1-17, mean 8.2) fulfilled the inclusion criteria, 67 of the 113 were on daily and 40 on intermittent steroids, while 6 were not on steroids. All were assessed using the 6 Minute Walk Test (6MWT), the North Star Ambulatory Assessment (NSAA) and timed test. RESULTS On the 6MWT there was an average overall decline of -22.7 (SD 81.0) in the first year and of -64.7 (SD 123.1) in the second year. On the NSAA the average overall decline was of -1.86 (SD 4.21) in the first year and of -2.98 (SD 5.19) in the second year. Fourteen children lost ambulation, one in the first year and the other 13 in the second year of the study. A distance of at least 330 meters on the 6MWT, or a NSAA score of 18 at baseline reduced significantly the risk of losing ambulation within 2 years. CONCLUSIONS These results can be of help at the time of using inclusion criteria for a study in ambulant patients in order to minimize the risk of patients who may lose ambulation within the time of the trial.
Related Publications
Elena Stacy Mazzone, and
Marika Pane, and
Maria Pia Sormani, and
Roberta Scalise, and
Angela Berardinelli, and
Sonia Messina, and
Yvan Torrente, and
Adele D'Amico, and
Luca Doglio, and
Emanuela Viggiano, and
Paola D'Ambrosio, and
Filippo Cavallaro, and
Silvia Frosini, and
Luca Bello, and
Serena Bonfiglio, and
Roberto De Sanctis, and
Enrica Rolle, and
Flaviana Bianco, and
Francesca Magri, and
Francesca Rossi, and
Gessica Vasco, and
Gianluca Vita, and
Maria Chiara Motta, and
Maria Alice Donati, and
Michele Sacchini, and
Tiziana Mongini, and
Antonella Pini, and
Roberta Battini, and
Elena Pegoraro, and
Stefano Previtali, and
Sara Napolitano, and
Claudio Bruno, and
Luisa Politano, and
Giacomo Pietro Comi, and
Enrico Bertini, and
Eugenio Mercuri
January 2015,
PloS one,
Elena Stacy Mazzone, and
Marika Pane, and
Maria Pia Sormani, and
Roberta Scalise, and
Angela Berardinelli, and
Sonia Messina, and
Yvan Torrente, and
Adele D'Amico, and
Luca Doglio, and
Emanuela Viggiano, and
Paola D'Ambrosio, and
Filippo Cavallaro, and
Silvia Frosini, and
Luca Bello, and
Serena Bonfiglio, and
Roberto De Sanctis, and
Enrica Rolle, and
Flaviana Bianco, and
Francesca Magri, and
Francesca Rossi, and
Gessica Vasco, and
Gianluca Vita, and
Maria Chiara Motta, and
Maria Alice Donati, and
Michele Sacchini, and
Tiziana Mongini, and
Antonella Pini, and
Roberta Battini, and
Elena Pegoraro, and
Stefano Previtali, and
Sara Napolitano, and
Claudio Bruno, and
Luisa Politano, and
Giacomo Pietro Comi, and
Enrico Bertini, and
Eugenio Mercuri
November 2019,
Neuromuscular disorders : NMD,
Elena Stacy Mazzone, and
Marika Pane, and
Maria Pia Sormani, and
Roberta Scalise, and
Angela Berardinelli, and
Sonia Messina, and
Yvan Torrente, and
Adele D'Amico, and
Luca Doglio, and
Emanuela Viggiano, and
Paola D'Ambrosio, and
Filippo Cavallaro, and
Silvia Frosini, and
Luca Bello, and
Serena Bonfiglio, and
Roberto De Sanctis, and
Enrica Rolle, and
Flaviana Bianco, and
Francesca Magri, and
Francesca Rossi, and
Gessica Vasco, and
Gianluca Vita, and
Maria Chiara Motta, and
Maria Alice Donati, and
Michele Sacchini, and
Tiziana Mongini, and
Antonella Pini, and
Roberta Battini, and
Elena Pegoraro, and
Stefano Previtali, and
Sara Napolitano, and
Claudio Bruno, and
Luisa Politano, and
Giacomo Pietro Comi, and
Enrico Bertini, and
Eugenio Mercuri
April 2024,
Minerva pediatrics,
Elena Stacy Mazzone, and
Marika Pane, and
Maria Pia Sormani, and
Roberta Scalise, and
Angela Berardinelli, and
Sonia Messina, and
Yvan Torrente, and
Adele D'Amico, and
Luca Doglio, and
Emanuela Viggiano, and
Paola D'Ambrosio, and
Filippo Cavallaro, and
Silvia Frosini, and
Luca Bello, and
Serena Bonfiglio, and
Roberto De Sanctis, and
Enrica Rolle, and
Flaviana Bianco, and
Francesca Magri, and
Francesca Rossi, and
Gessica Vasco, and
Gianluca Vita, and
Maria Chiara Motta, and
Maria Alice Donati, and
Michele Sacchini, and
Tiziana Mongini, and
Antonella Pini, and
Roberta Battini, and
Elena Pegoraro, and
Stefano Previtali, and
Sara Napolitano, and
Claudio Bruno, and
Luisa Politano, and
Giacomo Pietro Comi, and
Enrico Bertini, and
Eugenio Mercuri
January 2016,
Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association,
Elena Stacy Mazzone, and
Marika Pane, and
Maria Pia Sormani, and
Roberta Scalise, and
Angela Berardinelli, and
Sonia Messina, and
Yvan Torrente, and
Adele D'Amico, and
Luca Doglio, and
Emanuela Viggiano, and
Paola D'Ambrosio, and
Filippo Cavallaro, and
Silvia Frosini, and
Luca Bello, and
Serena Bonfiglio, and
Roberto De Sanctis, and
Enrica Rolle, and
Flaviana Bianco, and
Francesca Magri, and
Francesca Rossi, and
Gessica Vasco, and
Gianluca Vita, and
Maria Chiara Motta, and
Maria Alice Donati, and
Michele Sacchini, and
Tiziana Mongini, and
Antonella Pini, and
Roberta Battini, and
Elena Pegoraro, and
Stefano Previtali, and
Sara Napolitano, and
Claudio Bruno, and
Luisa Politano, and
Giacomo Pietro Comi, and
Enrico Bertini, and
Eugenio Mercuri
December 2012,
Acta paediatrica (Oslo, Norway : 1992),
Elena Stacy Mazzone, and
Marika Pane, and
Maria Pia Sormani, and
Roberta Scalise, and
Angela Berardinelli, and
Sonia Messina, and
Yvan Torrente, and
Adele D'Amico, and
Luca Doglio, and
Emanuela Viggiano, and
Paola D'Ambrosio, and
Filippo Cavallaro, and
Silvia Frosini, and
Luca Bello, and
Serena Bonfiglio, and
Roberto De Sanctis, and
Enrica Rolle, and
Flaviana Bianco, and
Francesca Magri, and
Francesca Rossi, and
Gessica Vasco, and
Gianluca Vita, and
Maria Chiara Motta, and
Maria Alice Donati, and
Michele Sacchini, and
Tiziana Mongini, and
Antonella Pini, and
Roberta Battini, and
Elena Pegoraro, and
Stefano Previtali, and
Sara Napolitano, and
Claudio Bruno, and
Luisa Politano, and
Giacomo Pietro Comi, and
Enrico Bertini, and
Eugenio Mercuri
May 2003,
Clinical pediatrics,
Elena Stacy Mazzone, and
Marika Pane, and
Maria Pia Sormani, and
Roberta Scalise, and
Angela Berardinelli, and
Sonia Messina, and
Yvan Torrente, and
Adele D'Amico, and
Luca Doglio, and
Emanuela Viggiano, and
Paola D'Ambrosio, and
Filippo Cavallaro, and
Silvia Frosini, and
Luca Bello, and
Serena Bonfiglio, and
Roberto De Sanctis, and
Enrica Rolle, and
Flaviana Bianco, and
Francesca Magri, and
Francesca Rossi, and
Gessica Vasco, and
Gianluca Vita, and
Maria Chiara Motta, and
Maria Alice Donati, and
Michele Sacchini, and
Tiziana Mongini, and
Antonella Pini, and
Roberta Battini, and
Elena Pegoraro, and
Stefano Previtali, and
Sara Napolitano, and
Claudio Bruno, and
Luisa Politano, and
Giacomo Pietro Comi, and
Enrico Bertini, and
Eugenio Mercuri
June 1990,
Developmental medicine and child neurology,
Elena Stacy Mazzone, and
Marika Pane, and
Maria Pia Sormani, and
Roberta Scalise, and
Angela Berardinelli, and
Sonia Messina, and
Yvan Torrente, and
Adele D'Amico, and
Luca Doglio, and
Emanuela Viggiano, and
Paola D'Ambrosio, and
Filippo Cavallaro, and
Silvia Frosini, and
Luca Bello, and
Serena Bonfiglio, and
Roberto De Sanctis, and
Enrica Rolle, and
Flaviana Bianco, and
Francesca Magri, and
Francesca Rossi, and
Gessica Vasco, and
Gianluca Vita, and
Maria Chiara Motta, and
Maria Alice Donati, and
Michele Sacchini, and
Tiziana Mongini, and
Antonella Pini, and
Roberta Battini, and
Elena Pegoraro, and
Stefano Previtali, and
Sara Napolitano, and
Claudio Bruno, and
Luisa Politano, and
Giacomo Pietro Comi, and
Enrico Bertini, and
Eugenio Mercuri
October 1986,
Developmental medicine and child neurology,
Elena Stacy Mazzone, and
Marika Pane, and
Maria Pia Sormani, and
Roberta Scalise, and
Angela Berardinelli, and
Sonia Messina, and
Yvan Torrente, and
Adele D'Amico, and
Luca Doglio, and
Emanuela Viggiano, and
Paola D'Ambrosio, and
Filippo Cavallaro, and
Silvia Frosini, and
Luca Bello, and
Serena Bonfiglio, and
Roberto De Sanctis, and
Enrica Rolle, and
Flaviana Bianco, and
Francesca Magri, and
Francesca Rossi, and
Gessica Vasco, and
Gianluca Vita, and
Maria Chiara Motta, and
Maria Alice Donati, and
Michele Sacchini, and
Tiziana Mongini, and
Antonella Pini, and
Roberta Battini, and
Elena Pegoraro, and
Stefano Previtali, and
Sara Napolitano, and
Claudio Bruno, and
Luisa Politano, and
Giacomo Pietro Comi, and
Enrico Bertini, and
Eugenio Mercuri
April 2021,
Neuromuscular disorders : NMD,
Elena Stacy Mazzone, and
Marika Pane, and
Maria Pia Sormani, and
Roberta Scalise, and
Angela Berardinelli, and
Sonia Messina, and
Yvan Torrente, and
Adele D'Amico, and
Luca Doglio, and
Emanuela Viggiano, and
Paola D'Ambrosio, and
Filippo Cavallaro, and
Silvia Frosini, and
Luca Bello, and
Serena Bonfiglio, and
Roberto De Sanctis, and
Enrica Rolle, and
Flaviana Bianco, and
Francesca Magri, and
Francesca Rossi, and
Gessica Vasco, and
Gianluca Vita, and
Maria Chiara Motta, and
Maria Alice Donati, and
Michele Sacchini, and
Tiziana Mongini, and
Antonella Pini, and
Roberta Battini, and
Elena Pegoraro, and
Stefano Previtali, and
Sara Napolitano, and
Claudio Bruno, and
Luisa Politano, and
Giacomo Pietro Comi, and
Enrico Bertini, and
Eugenio Mercuri
October 2021,
Gait & posture,
