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Cu-catalyzed direct C-H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles. 2013
Zengyang Xie, and
Xiaojun Zhu, and
Yangfan Guan, and
Dunru Zhu, and
Hongwen Hu, and
Chen Lin, and
Yi Pan, and
Juli Jiang, and
Leyong Wang
Key Laboratory of Mesoscopic Chemistry of Ministry of Education, Center for Multimolecular Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
An efficient, regioselective C-5 arylation of thiazolo[3,2-b]-1,2,4-triazoles catalyzed by a simple copper catalyst was developed. This arylation proceeded smoothly and tolerated a variety of functional groups (44 examples). A wide range of functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives were obtained in high yields (up to 99% yield). Possible catalytic cycles of the arylation were also discussed.
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