Biomaterial Database

An unusual presentation of chronic graft-versus-host disease in an unrelated bone marrow transplantation. 1990

F G LeVeque

Harper Hospital, Detroit, Michigan.

The case described is that of an unrelated bone marrow transplantation in a 43-year-old man. Although the major histocompatibility complex met the criteria for a perfect genotypic match, de novo graft-versus-host disease developed with unusual manifestations involving structures of the oral cavity and associated areas. The loss of taste and smell, as well as profound xerostomia, was treated by stimulating salivary flow. Synergistic sialagogues were used with the hope that an increase in salivary production would mediate an improvement in taste and smell.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002908	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D006086	Graft vs Host Disease	The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.	Graft-Versus-Host Disease,Homologous Wasting Disease,Runt Disease,Graft-vs-Host Disease,Disease, Graft-Versus-Host,Disease, Graft-vs-Host,Disease, Homologous Wasting,Disease, Runt,Diseases, Graft-Versus-Host,Diseases, Graft-vs-Host,Graft Versus Host Disease,Graft-Versus-Host Diseases,Graft-vs-Host Diseases
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000370	Ageusia	Complete or severe loss of the subjective sense of taste, frequently accompanied by OLFACTION DISORDERS.	Ageusia, Hysterical,Hypogeusia,Loss of Taste,Taste-Blindness,Ageusias, Hysterical,Hypogeusias,Hysterical Ageusia,Hysterical Ageusias,Taste Blindness,Taste Loss
D000781	Anethole Trithione	Choleretic used to allay dry mouth and constipation due to tranquilizers.	Anetholtrithion,Trithioanethol,Trithioparamethoxyphenylpropene,Anethol Dithiolthione,Anetholetrithione,Anetholtrithione,Anisyldithiolthionine,Felviten,Heporal,Mucinol,SL-25,Sialor,Sonicur,Sulfarlem,Sulfralem,Tiotrifar,Trithio,Dithiolthione, Anethol,SL 25,Trithione, Anethole
D000857	Olfaction Disorders	Impaired ability to smell. This may be caused by OLFACTORY NERVE DISEASES; PARANASAL SINUS DISEASES; viral RESPIRATORY TRACT INFECTIONS; CRANIOCEREBRAL TRAUMA; SMOKING; and other conditions.	Impaired Olfaction,Olfactory Impairment,Paraosmia,Parosmia,Phantosmia,Smell Disorders,Smell Dysfunction,Cacosmia,Dysosmia,Cacosmias,Dysfunction, Smell,Dysosmias,Impaired Olfactions,Impairment, Olfactory,Olfaction Disorder,Olfaction, Impaired,Olfactions, Impaired,Paraosmias,Parosmias,Phantosmias,Smell Disorder
D013651	Taste Disorders	Conditions characterized by an alteration in gustatory function or perception. Taste disorders are frequently associated with OLFACTION DISORDERS. Additional potential etiologies include METABOLIC DISEASES; DRUG TOXICITY; and taste pathway disorders (e.g., TASTE BUD diseases; FACIAL NERVE DISEASES; GLOSSOPHARYNGEAL NERVE DISEASES; and BRAIN STEM diseases).	Taste Disorder, Primary,Taste Disorder, Secondary,Taste Dysfunction,Taste, Metallic,Taste Disorder, Anterior Tongue,Taste Disorder, Posterior Tongue,Taste Disorder, Primary, Bitter,Taste Disorder, Primary, Salt,Taste Disorder, Primary, Sweet,Taste Disorder, Secondary, Bitter,Taste Disorder, Secondary, Salt,Taste Disorder, Secondary, Sweet,Dysfunction, Taste,Metallic Taste,Metallic Tastes,Primary Taste Disorder,Primary Taste Disorders,Secondary Taste Disorder,Secondary Taste Disorders,Taste Disorder,Taste Disorders, Primary,Taste Disorders, Secondary,Tastes, Metallic
D014987	Xerostomia	Decreased salivary flow.	Asialia,Hyposalivation,Mouth Dryness,Asialias,Dryness, Mouth,Hyposalivations,Xerostomias