BIOMAT Database Logo BIOMAT Database Logo

Serum osteocalcin (BGP) levels in normal men: a longitudinal evaluation reveals an age-associated increase. 1990

E S Orwoll, and L J Deftos
Medical Service, Portland VA Medical Center, OR.

Serum levels of bone gla protein (BGP) have been reported to increase with aging and hence to reflect an age-related increase in bone remodeling activity. To evaluate the relationship between aging and serum BGP levels in a study of longitudinal design, we measured BGP concentrations in 77 normal men at 6 month intervals over a 3 year period. Mean BGP levels at the onset (4.95 +/- 1.5 ng/ml) increased significantly during the study (p = 0.004), and the mean of individual BGP slopes was positive (0.38 +/- 0.6 ng/ml per year, p = 0.0001). The rate of change in BGP was not related to serum creatinine levels or dietary calcium intake.

UI MeSH Term Description Entries
D008137 Longitudinal Studies Studies in which variables relating to an individual or group of individuals are assessed over a period of time. Bogalusa Heart Study,California Teachers Study,Framingham Heart Study,Jackson Heart Study,Longitudinal Survey,Tuskegee Syphilis Study,Bogalusa Heart Studies,California Teachers Studies,Framingham Heart Studies,Heart Studies, Bogalusa,Heart Studies, Framingham,Heart Studies, Jackson,Heart Study, Bogalusa,Heart Study, Framingham,Heart Study, Jackson,Jackson Heart Studies,Longitudinal Study,Longitudinal Surveys,Studies, Bogalusa Heart,Studies, California Teachers,Studies, Jackson Heart,Studies, Longitudinal,Study, Bogalusa Heart,Study, California Teachers,Study, Longitudinal,Survey, Longitudinal,Surveys, Longitudinal,Syphilis Studies, Tuskegee,Syphilis Study, Tuskegee,Teachers Studies, California,Teachers Study, California,Tuskegee Syphilis Studies
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D003404 Creatinine Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging

Related Publications

E S Orwoll, and L J Deftos
Influence of sex, age, and menopause in serum osteocalcin (BGP) levels.
December 1990, Klinische Wochenschrift,
E S Orwoll, and L J Deftos
Serum osteocalcin (BGP) in tumor-associated hypercalcemia.
December 1986, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
E S Orwoll, and L J Deftos
Serum osteocalcin levels in normal humans of different sex and age. An epidemiological study.
January 1988, Panminerva medica,
E S Orwoll, and L J Deftos
Effect of dietary calcium on serum BGP (osteocalcin).
April 1991, Endocrinologia japonica,
E S Orwoll, and L J Deftos
Serum osteocalcin levels of normal children in Taiwan.
January 1997, Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui,
E S Orwoll, and L J Deftos
[Serum osteocalcin (BGP) as a "marker" of bone mineral content in postmenopausal women].
January 1989, Gynakologische Rundschau,
E S Orwoll, and L J Deftos
Epidermal Dysfunction Leads to an Age-Associated Increase in Levels of Serum Inflammatory Cytokines.
June 2017, The Journal of investigative dermatology,
E S Orwoll, and L J Deftos
BGP (osteocalcin, bone-Gla-protein) in involutional osteoporosis.
June 1989, Clinical rheumatology,
E S Orwoll, and L J Deftos
Serum osteocalcin levels in normal subjects and patients with primary hyperparathyroidism.
December 1985, Experimental and clinical endocrinology,
E S Orwoll, and L J Deftos
Serum osteocalcin levels are inversely associated with abdominal aortic calcification in men with type 2 diabetes mellitus.
August 2013, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA,
Copied contents to your clipboard!