Effects of temporary vascular occluder poloxamer 407 gel on the endothelium. 2013

Arif Gucu, and Ilkin Cavusoglu, and Onder Bozkurt, and Cuneyt Eris, and Faruk Toktas, and Tugrul Goncu, and Ahmet Ozyazicioglu
Department of Cardiovascular Surgery, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. dr.arifgucu@gmail.com

BACKGROUND Coronary occlusion techniques during OPCAB may lead to an endothelial damage to the target vessel. The adverse effects of these techniques are well-known, and researches have been trying to find out new materials to occlude the coronary artery without an endothelial damage. In the present study, we investigate to the endothelial damage in the rat aorta which is occluded by Poloxamer 407 gel. METHODS Forty-five rats were randomized in three groups: (1) segment of the aorta was occluded with Poloxamer 407 gel in P 407 group; (2) segment of the aorta was occluded with microvascular clamp in MV clamp group; and (3) no onclusion was available in the Control group. The rats were sacrificed of observation, and a 15mm segment of the aorta was obtained as a specimen. Integrity of the endothelial lining was observed with a scanning electron microscopy. RESULTS Scanning electron microscopy revealed a statistically significant difference among the 3 groups (p<0,001) using the SPSS 13.0 test. No difference was found between the Control group and the P 407 group (p=0,059). The differences between MV clamp-Control group (p<0,001) and MV clamp-P 407 group were statistically significant (p<0,002). CONCLUSIONS We suggest that Poloxamer 407 gel occlusion may be a safer and more effective method compared to the microvascular clamp occlusion.

UI MeSH Term Description Entries
D008855 Microscopy, Electron, Scanning Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY. Scanning Electron Microscopy,Electron Scanning Microscopy,Electron Microscopies, Scanning,Electron Microscopy, Scanning,Electron Scanning Microscopies,Microscopies, Electron Scanning,Microscopies, Scanning Electron,Microscopy, Electron Scanning,Microscopy, Scanning Electron,Scanning Electron Microscopies,Scanning Microscopies, Electron,Scanning Microscopy, Electron
D004730 Endothelium, Vascular Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components. Capillary Endothelium,Vascular Endothelium,Capillary Endotheliums,Endothelium, Capillary,Endotheliums, Capillary,Endotheliums, Vascular,Vascular Endotheliums
D005260 Female Females
D006489 Hemostatic Techniques Techniques for controlling bleeding. Hemostatic Technics,Hemostatic Technic,Hemostatic Technique,Technic, Hemostatic,Technics, Hemostatic,Technique, Hemostatic,Techniques, Hemostatic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001011 Aorta The main trunk of the systemic arteries. Aortas
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D054059 Coronary Occlusion Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS. Coronary Occlusions,Occlusion, Coronary,Occlusions, Coronary
D018709 Statistics, Nonparametric A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5) Kolmogorov-Smirnov Test,Kruskal-Wallis H Statistic,Mann-Whitney U Test,Rank-Sum Tests,Spearman Rank Correlation Coefficient,Wilcox Test,Wilcoxon Rank Test,Non-Parametric Statistics,Nonparametric Statistics,Statistics, Non-Parametric,Kolmogorov Smirnov Test,Mann Whitney U Test,Non Parametric Statistics,Rank Sum Tests,Rank Test, Wilcoxon,Rank-Sum Test,Statistics, Non Parametric,Test, Kolmogorov-Smirnov,Test, Mann-Whitney U,Test, Rank-Sum,Test, Wilcox,Test, Wilcoxon Rank,Tests, Rank-Sum,U Test, Mann-Whitney

Related Publications

Arif Gucu, and Ilkin Cavusoglu, and Onder Bozkurt, and Cuneyt Eris, and Faruk Toktas, and Tugrul Goncu, and Ahmet Ozyazicioglu
May 2006, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Arif Gucu, and Ilkin Cavusoglu, and Onder Bozkurt, and Cuneyt Eris, and Faruk Toktas, and Tugrul Goncu, and Ahmet Ozyazicioglu
August 2004, Biomaterials,
Arif Gucu, and Ilkin Cavusoglu, and Onder Bozkurt, and Cuneyt Eris, and Faruk Toktas, and Tugrul Goncu, and Ahmet Ozyazicioglu
August 2021, Materials (Basel, Switzerland),
Arif Gucu, and Ilkin Cavusoglu, and Onder Bozkurt, and Cuneyt Eris, and Faruk Toktas, and Tugrul Goncu, and Ahmet Ozyazicioglu
August 2013, International journal of pharmaceutics,
Arif Gucu, and Ilkin Cavusoglu, and Onder Bozkurt, and Cuneyt Eris, and Faruk Toktas, and Tugrul Goncu, and Ahmet Ozyazicioglu
March 2007, International journal of pharmaceutics,
Arif Gucu, and Ilkin Cavusoglu, and Onder Bozkurt, and Cuneyt Eris, and Faruk Toktas, and Tugrul Goncu, and Ahmet Ozyazicioglu
January 1996, Pharmacotherapy,
Arif Gucu, and Ilkin Cavusoglu, and Onder Bozkurt, and Cuneyt Eris, and Faruk Toktas, and Tugrul Goncu, and Ahmet Ozyazicioglu
July 2018, International journal of pharmaceutics,
Arif Gucu, and Ilkin Cavusoglu, and Onder Bozkurt, and Cuneyt Eris, and Faruk Toktas, and Tugrul Goncu, and Ahmet Ozyazicioglu
April 2011, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy,
Arif Gucu, and Ilkin Cavusoglu, and Onder Bozkurt, and Cuneyt Eris, and Faruk Toktas, and Tugrul Goncu, and Ahmet Ozyazicioglu
January 1999, Life sciences,
Arif Gucu, and Ilkin Cavusoglu, and Onder Bozkurt, and Cuneyt Eris, and Faruk Toktas, and Tugrul Goncu, and Ahmet Ozyazicioglu
March 2021, Contact dermatitis,
Copied contents to your clipboard!