The purpose of this study was to investigate the symptomatic and physiologic responses during moderate to heavy resistance exercise in a population with coronary artery disease. After at least 12 weeks of aerobic training without experiencing complications, 15 male cardiac patients were selected for the study. Approximately one week after a graded exercise test (GXT), each patient's maximal voluntary contraction (MVC) was determined on seven upper-body Nautilus machines. Resistance exercises, consisting of two sets of seven repetitions at a submaximal intensity (75% MVC) for each exercise, were then performed on two nonconsecutive occasions; symptomatic, hemodynamic, and electrocardiographic responses were recorded and analyzed for patients both on and off beta-blockers. During the MVC and submaximal exercise trials, no significant untoward hemodynamic change was noted with heart rate, systolic blood pressure, diastolic blood pressure, or rate pressure product, and no patient complained of angina or developed ischemic electrocardiographic changes. However, three incidences of premature ventricular contractions (PVCs) occurred. During the GXT, there were 13 incidences of angina, ischemia, or PVCs. Patients taking beta-blockers had significantly lower (p less than .01) values for heart rate and rate pressure product during the GXT, MVC, and submaximal trials. These results suggest that clinically stable, aerobically trained cardiac patients may perform moderate to heavy resistance exercises without experiencing complications.