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Synthesis, chemical characterization and biological evaluation of new platinum (II)-sulfonamide complexes. 1990
D G Craciunescu, and
V Scarcia, and
A Furlani, and
E Parrondo Iglesias, and
L Ravalico, and
A Doadrio
Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, University of Madrid, Spain.
Six new platinum (II)-sulfonamide complexes were examined for their in vitro cytostatic properties as well as in vivo antitumour effect against three experimental murine tumours. The possible antitrypanosomic in vivo activity against T. brucei, T. congolense and T. cruzi infections was also evaluated. The synthesis and chemical characterization of new complexes is reported. Only two sulfadiazine derivatives appeared to be effective mainly against Ehrlich ascites but in a smaller extent than cisplatin. A satisfactory correlation between antitumour and antitrypanosomic activity was found.
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