-transparent.png){kind=logo}
The preparation and in vitro antifungal activity of a novel series of cis-5-alkyl (or alkenyl)-3-phenyl-3-(1H-azol-1-ylmethyl)-2-methylisoxazol idines are described. The overall activity of the 3-(1H-imidazol-1-ylmethyl) analogues was higher than that of the corresponding 3-(1H-1,2,4-triazol-1-ylmethyl) derivatives. Compound 4b emerged as the most potent derivative. When compared to ketoconazole, several of the analogues tested demonstrated equipotent or superior activity against Trichophyton and Candida sp.
Related Publications
G A Bennett, and
P A Swift, and
G B Mullen, and
J T Mitchell, and
S D Allen, and
V S Georgiev
January 1990,
Arzneimittel-Forschung,
G A Bennett, and
P A Swift, and
G B Mullen, and
J T Mitchell, and
S D Allen, and
V S Georgiev
December 1988,
Journal of pharmaceutical sciences,
G A Bennett, and
P A Swift, and
G B Mullen, and
J T Mitchell, and
S D Allen, and
V S Georgiev
January 1988,
Annals of the New York Academy of Sciences,
G A Bennett, and
P A Swift, and
G B Mullen, and
J T Mitchell, and
S D Allen, and
V S Georgiev
September 1989,
Archiv der Pharmazie,
G A Bennett, and
P A Swift, and
G B Mullen, and
J T Mitchell, and
S D Allen, and
V S Georgiev
January 1988,
Annals of the New York Academy of Sciences,
G A Bennett, and
P A Swift, and
G B Mullen, and
J T Mitchell, and
S D Allen, and
V S Georgiev
January 1988,
Annals of the New York Academy of Sciences,
G A Bennett, and
P A Swift, and
G B Mullen, and
J T Mitchell, and
S D Allen, and
V S Georgiev
October 1988,
Journal of medicinal chemistry,
G A Bennett, and
P A Swift, and
G B Mullen, and
J T Mitchell, and
S D Allen, and
V S Georgiev
January 1988,
Annals of the New York Academy of Sciences,
G A Bennett, and
P A Swift, and
G B Mullen, and
J T Mitchell, and
S D Allen, and
V S Georgiev
January 1988,
Annals of the New York Academy of Sciences,
G A Bennett, and
P A Swift, and
G B Mullen, and
J T Mitchell, and
S D Allen, and
V S Georgiev
January 1988,
Annals of the New York Academy of Sciences,
