Types of HLA in the bladder transitional cell carcinoma (TCC). 2013

Erkan Yılmaz, and Ali Uğur Özalp, and Arman Cekmen, and Bülent Eren, and Bülent Onal, and Emre Akkuş, and Ergun Erdoğan
1Blood Bank, Tissue Typing Laboratory, 2Urology Department; School of Medicine, Istanbul University, Cerrahpaşa, 3Bursa Morgue Department, Council of Forensic Medicine of Turkey, 3Bursa Morgue Department, Council of Forensic Medicine of Tur- key, Bursa, 4Pediatric Surgery Department, Cerrahpasa School of Medicine, Istanbul University; Turkey.

HLA plays a complementary role in the interaction between tumor and body immunology. The aim of this study was to determine the existence of the association between the HLA system and transitional cell carcinoma (TCC). Using standard micro-lymphocytotoxic method of Terasaki, HLA-A, B, DR and DQ antigen types of 30 patients with TCC of the bladder were compared with the control group (30 healthy people). In the TCC patient group, HLA -DQ6(1) and HLA -DQ7(3) antigens were detected with a significantly higher frequency than in the control group (p=0.018 and p=0.038, respectively), whereas HLA-A10, B4, DR53 and DQ1 antigens were detected with significantly higher frequency in the control group (p less 0.05 in all). It suggests that patients who had the antigens detected were at higher risk of TCC, and the ones who had the antigens displaying protective features as were detected in the control group, were at lesser risk.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009361 Neoplasm Invasiveness Ability of neoplasms to infiltrate and actively destroy surrounding tissue. Invasiveness, Neoplasm,Neoplasm Invasion,Invasion, Neoplasm
D009367 Neoplasm Staging Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D001749 Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER. Bladder Cancer,Bladder Neoplasms,Cancer of Bladder,Bladder Tumors,Cancer of the Bladder,Malignant Tumor of Urinary Bladder,Neoplasms, Bladder,Urinary Bladder Cancer,Bladder Cancers,Bladder Neoplasm,Bladder Tumor,Cancer, Bladder,Cancer, Urinary Bladder,Neoplasm, Bladder,Neoplasm, Urinary Bladder,Tumor, Bladder,Tumors, Bladder,Urinary Bladder Neoplasm
D002295 Carcinoma, Transitional Cell A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS. Carcinomas, Transitional Cell,Cell Carcinoma, Transitional,Cell Carcinomas, Transitional,Transitional Cell Carcinoma,Transitional Cell Carcinomas
D005260 Female Females
D006683 HLA-DQ Antigens A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. HLA-DC Antigens,HLA-MB Antigens,HLA-DC,HLA-DQ,HLA-DS,HLA-DS Antigens,HLA-LB,HLA-LB Antigens,HLA-MB,Antigens, HLA-DC,Antigens, HLA-DQ,Antigens, HLA-DS,Antigens, HLA-LB,Antigens, HLA-MB,HLA DC Antigens,HLA DQ Antigens,HLA DS Antigens,HLA LB Antigens,HLA MB Antigens
D006684 HLA-DR Antigens A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS. HLA-DR,Antigens, HLA-DR,HLA DR Antigens

Related Publications

Erkan Yılmaz, and Ali Uğur Özalp, and Arman Cekmen, and Bülent Eren, and Bülent Onal, and Emre Akkuş, and Ergun Erdoğan
February 1996, Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica,
Erkan Yılmaz, and Ali Uğur Özalp, and Arman Cekmen, and Bülent Eren, and Bülent Onal, and Emre Akkuş, and Ergun Erdoğan
June 2008, BJU international,
Erkan Yılmaz, and Ali Uğur Özalp, and Arman Cekmen, and Bülent Eren, and Bülent Onal, and Emre Akkuş, and Ergun Erdoğan
August 2008, BJU international,
Erkan Yılmaz, and Ali Uğur Özalp, and Arman Cekmen, and Bülent Eren, and Bülent Onal, and Emre Akkuş, and Ergun Erdoğan
October 2006, TheScientificWorldJournal,
Erkan Yılmaz, and Ali Uğur Özalp, and Arman Cekmen, and Bülent Eren, and Bülent Onal, and Emre Akkuş, and Ergun Erdoğan
January 1990, Urologia internationalis,
Erkan Yılmaz, and Ali Uğur Özalp, and Arman Cekmen, and Bülent Eren, and Bülent Onal, and Emre Akkuş, and Ergun Erdoğan
October 1979, The Journal of urology,
Erkan Yılmaz, and Ali Uğur Özalp, and Arman Cekmen, and Bülent Eren, and Bülent Onal, and Emre Akkuş, and Ergun Erdoğan
December 2008, Journal of the Egyptian National Cancer Institute,
Erkan Yılmaz, and Ali Uğur Özalp, and Arman Cekmen, and Bülent Eren, and Bülent Onal, and Emre Akkuş, and Ergun Erdoğan
November 1999, Cancer research,
Erkan Yılmaz, and Ali Uğur Özalp, and Arman Cekmen, and Bülent Eren, and Bülent Onal, and Emre Akkuş, and Ergun Erdoğan
November 1995, Gynecologic oncology,
Erkan Yılmaz, and Ali Uğur Özalp, and Arman Cekmen, and Bülent Eren, and Bülent Onal, and Emre Akkuş, and Ergun Erdoğan
January 1984, Progress in clinical and biological research,
Copied contents to your clipboard!