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Three indices of circulating parathyroid hormone (PTH) activity were compared between two groups: the first a group of 23 patients from three large kindreds with autosomal dominant hypercalcemia without hypercalciuria [familial hypocalciuric hypercalcemia (FHH)] and the second a group of 64 patients with typical primary hyperparathyroidism (1HPT) manifesting comparable hypercalcemia. The group with 1HPT differed from normal with respect to plasma PTH 1HPT concentration (normal, less 0.2 ng/ml), urinary cAMP excretion per 100 ml glomerular filtrate (U cAMP/GF) (normal, 2.3 x/divided by 0.6 nmol/100 ml glomerular filtrate; mean, x/divided 1 SD), and renal tubular maximum of phosphate transport corrected for glomerular filtration rate (TMP/GFR; normal, 3.4 +/- 0.4 mg/dl; mean, +/- 1 SD). The group with 1HPT also diverged significantly from the group with FHH for all three indices: for PTH, 0.37 x/divided by .48 vs. 0.25 x/divided .46 (P less than 0.05); for UcAMP/GF, 4.3 x/divided by .53 vs. 2.6 x/divided .60 (P less than 0.0005); and for TMP/GFR, 2.0 +/- 0.6 vs. 2.6 +/- 0.7 (P less than 0.01). The between-group differences for all three indices were also significant after adjustment for their variation with serum calcium. However, only the difference in TMP/GFR remained significant after adjustment for covariance attributable to serum calcium concentration, age, and creatinine clearance. The group with FHH differed from normal for TMP/GFR but not for UcAMP/GF. However, analysis of changes in UcAMP/GF and serum calcium concentration around the time of parathyroidectomy in three patients with FHH suggested that the parathyroid glands contributed to the abnormalities of mineral homeostasis in at least one. It was concluded that higher serum concentrations of PTH do not account for the lower renal clearance of calcium and magnesium in FHH calcium concentration, the group with FHH showed indices suggesting lower circulating PTH activity than the group with 1HPT.
S J Marx, and
A M Spiegel, and
E M Brown, and
R Windeck, and
D G Gardner, and
R W Downs, and
M Attie, and
G D Aurbach
February 1982,
The Western journal of medicine,
S J Marx, and
A M Spiegel, and
E M Brown, and
R Windeck, and
D G Gardner, and
R W Downs, and
M Attie, and
G D Aurbach
August 1982,
American journal of diseases of children (1960),
S J Marx, and
A M Spiegel, and
E M Brown, and
R Windeck, and
D G Gardner, and
R W Downs, and
M Attie, and
G D Aurbach
January 2013,
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists,
S J Marx, and
A M Spiegel, and
E M Brown, and
R Windeck, and
D G Gardner, and
R W Downs, and
M Attie, and
G D Aurbach
December 2008,
European journal of endocrinology,
S J Marx, and
A M Spiegel, and
E M Brown, and
R Windeck, and
D G Gardner, and
R W Downs, and
M Attie, and
G D Aurbach
July 1983,
Acta paediatrica Scandinavica,
S J Marx, and
A M Spiegel, and
E M Brown, and
R Windeck, and
D G Gardner, and
R W Downs, and
M Attie, and
G D Aurbach
June 1984,
The American journal of medicine,
S J Marx, and
A M Spiegel, and
E M Brown, and
R Windeck, and
D G Gardner, and
R W Downs, and
M Attie, and
G D Aurbach
March 2002,
Surgery,
S J Marx, and
A M Spiegel, and
E M Brown, and
R Windeck, and
D G Gardner, and
R W Downs, and
M Attie, and
G D Aurbach
January 2018,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
S J Marx, and
A M Spiegel, and
E M Brown, and
R Windeck, and
D G Gardner, and
R W Downs, and
M Attie, and
G D Aurbach
April 1982,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
S J Marx, and
A M Spiegel, and
E M Brown, and
R Windeck, and
D G Gardner, and
R W Downs, and
M Attie, and
G D Aurbach
January 2012,
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists,
