BIOMAT Database Logo BIOMAT Database Logo

Purification of 2-[18F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction. 2013

Mark D Tarn, and Giancarlo Pascali, and Francesco De Leonardis, and Paul Watts, and Piero A Salvadori, and Nicole Pamme
Department of Chemistry, The University of Hull, Cottingham Road, Hull HU6 7RX, UK.

Microfluidic devices have shown great potential for the production of positron emission tomography (PET) radiotracers, but most devices have focused only on the synthesis step of the procedure, typically neglecting the other important steps such as [(18)F]fluoride pre-concentration and radiotracer purification that could equally benefit from miniaturisation. Here, we demonstrate the development of microfluidic modules for the purification of PET radiotracers, particularly 2-[(18)F]fluoro-2-deoxy-d-glucose ([(18)F]FDG), via the use of on-chip solid-phase extraction (SPE). In these initial tests, the SPE modules were able to yield [(18)F]FDG with up to 90% radiochemical purity, and methods are proposed for further increasing this value.

UI MeSH Term Description Entries
D046210 Microfluidic Analytical Techniques Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids. Microfluidic Analysis,Analyses, Microfluidic,Analysis, Microfluidic,Analytical Technique, Microfluidic,Analytical Techniques, Microfluidic,Microfluidic Analyses,Microfluidic Analytical Technique,Technique, Microfluidic Analytical,Techniques, Microfluidic Analytical
D052616 Solid Phase Extraction An extraction method that separates analytes using a solid phase and a liquid phase. It is used for preparative sample cleanup before analysis by CHROMATOGRAPHY and other analytical methods. Extraction, Solid Phase,Extractions, Solid Phase,Solid Phase Extractions
D019275 Radiopharmaceuticals Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) Radiopharmaceutical
D019788 Fluorodeoxyglucose F18 The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162) 18F Fluorodeoxyglucose,18FDG,2-Fluoro-2-deoxy-D-glucose,2-Fluoro-2-deoxyglucose,Fludeoxyglucose F 18,18F-FDG,Fluorine-18-fluorodeoxyglucose,Fluorodeoxyglucose F 18,2 Fluoro 2 deoxy D glucose,2 Fluoro 2 deoxyglucose,F 18, Fludeoxyglucose,F 18, Fluorodeoxyglucose,F18, Fluorodeoxyglucose,Fluorine 18 fluorodeoxyglucose,Fluorodeoxyglucose, 18F

Related Publications

Mark D Tarn, and Giancarlo Pascali, and Francesco De Leonardis, and Paul Watts, and Piero A Salvadori, and Nicole Pamme
A solid-phase route to 18F-labeled tracers, exemplified by the synthesis of [18F]2-Fluoro-2-deoxy-D-glucose.
January 2007, Angewandte Chemie (International ed. in English),
Mark D Tarn, and Giancarlo Pascali, and Francesco De Leonardis, and Paul Watts, and Piero A Salvadori, and Nicole Pamme
Synthesis and purification of 2-deoxy-2-[18F]fluoro-D-glucose and 2-deoxy-2-[18F]fluoro-D-mannose: characterization of products by 1H- and 19F-NMR spectroscopy.
January 1986, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes,
Mark D Tarn, and Giancarlo Pascali, and Francesco De Leonardis, and Paul Watts, and Piero A Salvadori, and Nicole Pamme
Temporal analysis of myocardial glucose metabolism by 2-[18F]fluoro-2-deoxy-D-glucose.
October 1990, The American journal of physiology,
Mark D Tarn, and Giancarlo Pascali, and Francesco De Leonardis, and Paul Watts, and Piero A Salvadori, and Nicole Pamme
History of the first synthesis of 2-deoxy-2-fluoro-D-glucose the unlabeled forerunner of 2-deoxy-2-[18F]fluoro-D-glucose.
October 2002, Molecular imaging and biology,
Mark D Tarn, and Giancarlo Pascali, and Francesco De Leonardis, and Paul Watts, and Piero A Salvadori, and Nicole Pamme
Metabolism of 2-deoxy-2-[18F]fluoro-D-glucose: presence of 2-deoxy-2-[18F]fluoro-D-glucose 6-phosphate in plasma of mice, rats, and humans.
September 1987, Annals of nuclear medicine,
Mark D Tarn, and Giancarlo Pascali, and Francesco De Leonardis, and Paul Watts, and Piero A Salvadori, and Nicole Pamme
Preliminary imaging results with 18F-2-fluoro-2-deoxy-D-glucose.
August 1980, Journal of computer assisted tomography,
Mark D Tarn, and Giancarlo Pascali, and Francesco De Leonardis, and Paul Watts, and Piero A Salvadori, and Nicole Pamme
Direct labelling of peptides with 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG).
September 2009, Bioorganic & medicinal chemistry letters,
Mark D Tarn, and Giancarlo Pascali, and Francesco De Leonardis, and Paul Watts, and Piero A Salvadori, and Nicole Pamme
Fate of 2-deoxy-2-[18F]fluoro-D-glucose in hyperglycemic rats.
November 2000, International journal of molecular medicine,
Mark D Tarn, and Giancarlo Pascali, and Francesco De Leonardis, and Paul Watts, and Piero A Salvadori, and Nicole Pamme
[18F]-2-Fluoro-2-Deoxy-D-glucose-PET Assessment of Cervical Cancer.
April 2018, PET clinics,
Mark D Tarn, and Giancarlo Pascali, and Francesco De Leonardis, and Paul Watts, and Piero A Salvadori, and Nicole Pamme
Experiences with automated production of 2-[18F]-fluoro-2-deoxy-D-glucose.
January 1991, Acta radiologica. Supplementum,
Copied contents to your clipboard!