BIOMAT Database Logo BIOMAT Database Logo

Investigation of internal structure of fine granules by microtomography using synchrotron X-ray radiation. 2013

Shuji Noguchi, and Ryusuke Kajihara, and Yasunori Iwao, and Yukari Fujinami, and Yoshio Suzuki, and Yasuko Terada, and Kentaro Uesugi, and Keiko Miura, and Shigeru Itai
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

Computed tomography (CT) using synchrotron X-ray radiation was evaluated as a non-destructive structural analysis method for fine granules. Two kinds of granules have been investigated: a bromhexine hydrochloride (BHX)-layered Celphere CP-102 granule coated with pH-sensitive polymer Kollicoat Smartseal 30-D, and a wax-matrix granule constructed from acetaminophen (APAP), dibasic calcium phosphate dehydrate, and aminoalkyl methacrylate copolymer E (AMCE) manufactured by melt granulation. The diameters of both granules were 200-300 μm. CT analysis of CP-102 granule could visualize the laminar structures of BHX and Kollicoat layers, and also visualize the high talc-content regions in the Kollicoat layer that could not be detected by scanning electron microscopy. Moreover, CT analysis using X-ray energies above the absorption edge of Br specifically enhanced the contrast in the BHX layer. As for granules manufactured by melt granulation, CT analysis revealed that they had a small inner void space due to a uniform distribution of APAP and other excipients. The distribution of AMCE revealed by CT analysis was also found to involve in the differences of drug dissolution from the granules as described previously. These observations demonstrate that CT analysis using synchrotron X-ray radiation is a powerful method for the detailed internal structure analysis of fine granules.

UI MeSH Term Description Entries
D008353 Mannitol A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity. (L)-Mannitol,Osmitrol,Osmofundin
D008689 Methacrylates Acrylic acids or acrylates which are substituted in the C-2 position with a methyl group. Methacrylate
D008855 Microscopy, Electron, Scanning Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY. Scanning Electron Microscopy,Electron Scanning Microscopy,Electron Microscopies, Scanning,Electron Microscopy, Scanning,Electron Scanning Microscopies,Microscopies, Electron Scanning,Microscopies, Scanning Electron,Microscopy, Electron Scanning,Microscopy, Scanning Electron,Scanning Electron Microscopies,Scanning Microscopies, Electron,Scanning Microscopy, Electron
D010316 Particle Size Relating to the size of solids. Particle Sizes,Size, Particle,Sizes, Particle
D011728 Pyridones Pyridine derivatives with one or more keto groups on the ring. Pyridinones
D001964 Bromhexine A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744) Aparsonin,Bisolvon,Bromhexin,Bromhexin BC,Bromhexin Berlin-Chemie,Bromhexin-ratiopharm,Bromhexine Hydrochloride,Bromhexine Monohydrochloride,Brotussol,Darolan,Dur-Elix,Famel Bromhexine,Flegamin,Flubron,Hustentabs-ratiopharm,Mucohexine,NA-274,Quentan,Tesacof,bromhexin von ct,BC, Bromhexin,Bromhexin Berlin Chemie,Bromhexin BerlinChemie,Bromhexin ratiopharm,Bromhexine, Famel,Bromhexinratiopharm,Dur Elix,DurElix,Hustentabs ratiopharm,Hustentabsratiopharm,Hydrochloride, Bromhexine,Monohydrochloride, Bromhexine,NA 274,NA274,ct, bromhexin von,von ct, bromhexin
D002130 Calcium Phosphates Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements. Phosphates, Calcium
D002482 Cellulose A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations. Alphacel,Avicel,Heweten,Polyanhydroglucuronic Acid,Rayophane,Sulfite Cellulose,alpha-Cellulose,Acid, Polyanhydroglucuronic,alpha Cellulose
D004339 Drug Compounding The preparation, mixing, and assembly of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814). Drug Formulation,Drug Preparation,Drug Microencapsulation,Pharmaceutical Formulation,Compounding, Drug,Formulation, Drug,Formulation, Pharmaceutical,Microencapsulation, Drug,Preparation, Drug
D005079 Excipients Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc. Excipient,Stabilizing Agent,Stabilizing Agents,Suspending Agent,Suspending Agents,Agent, Stabilizing,Agent, Suspending,Agents, Stabilizing,Agents, Suspending

Related Publications

Shuji Noguchi, and Ryusuke Kajihara, and Yasunori Iwao, and Yukari Fujinami, and Yoshio Suzuki, and Yasuko Terada, and Kentaro Uesugi, and Keiko Miura, and Shigeru Itai
Noninvasive Investigation of Phloem Structure by 3D Synchrotron X-Ray Microtomography.
January 2019, Methods in molecular biology (Clifton, N.J.),
Shuji Noguchi, and Ryusuke Kajihara, and Yasunori Iwao, and Yukari Fujinami, and Yoshio Suzuki, and Yasuko Terada, and Kentaro Uesugi, and Keiko Miura, and Shigeru Itai
X-ray computed microtomography (microCT) using synchrotron radiation (SR).
January 1996, Progress in biophysics and molecular biology,
Shuji Noguchi, and Ryusuke Kajihara, and Yasunori Iwao, and Yukari Fujinami, and Yoshio Suzuki, and Yasuko Terada, and Kentaro Uesugi, and Keiko Miura, and Shigeru Itai
Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres.
February 2016, International journal of pharmaceutics,
Shuji Noguchi, and Ryusuke Kajihara, and Yasunori Iwao, and Yukari Fujinami, and Yoshio Suzuki, and Yasuko Terada, and Kentaro Uesugi, and Keiko Miura, and Shigeru Itai
Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction.
March 2013, International journal of pharmaceutics,
Shuji Noguchi, and Ryusuke Kajihara, and Yasunori Iwao, and Yukari Fujinami, and Yoshio Suzuki, and Yasuko Terada, and Kentaro Uesugi, and Keiko Miura, and Shigeru Itai
Pore-Scale Investigation of Dynamic Immiscible Displacement in Layered Media using Synchrotron X-ray Microtomography.
January 2022, Environmental science & technology,
Shuji Noguchi, and Ryusuke Kajihara, and Yasunori Iwao, and Yukari Fujinami, and Yoshio Suzuki, and Yasuko Terada, and Kentaro Uesugi, and Keiko Miura, and Shigeru Itai
Structure of tubulin rings studied by X-ray scattering using synchrotron radiation.
June 1983, Journal of molecular biology,
Shuji Noguchi, and Ryusuke Kajihara, and Yasunori Iwao, and Yukari Fujinami, and Yoshio Suzuki, and Yasuko Terada, and Kentaro Uesugi, and Keiko Miura, and Shigeru Itai
X-ray microtomography of biological tissues using laboratory and synchrotron sources.
August 1987, Biological trace element research,
Shuji Noguchi, and Ryusuke Kajihara, and Yasunori Iwao, and Yukari Fujinami, and Yoshio Suzuki, and Yasuko Terada, and Kentaro Uesugi, and Keiko Miura, and Shigeru Itai
Failure Analysis of Batteries Using Synchrotron-based Hard X-ray Microtomography.
August 2015, Journal of visualized experiments : JoVE,
Shuji Noguchi, and Ryusuke Kajihara, and Yasunori Iwao, and Yukari Fujinami, and Yoshio Suzuki, and Yasuko Terada, and Kentaro Uesugi, and Keiko Miura, and Shigeru Itai
Investigation of the microstructure and mineralogical composition of urinary calculi fragments by synchrotron radiation X-ray microtomography: a feasibility study.
August 2011, Urological research,
Shuji Noguchi, and Ryusuke Kajihara, and Yasunori Iwao, and Yukari Fujinami, and Yoshio Suzuki, and Yasuko Terada, and Kentaro Uesugi, and Keiko Miura, and Shigeru Itai
Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography.
May 2012, International journal of pharmaceutics,
Copied contents to your clipboard!