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The effects of phenylephrine and dopamine on cerebral blood flow, blood volume, and oxygenation were studied in young rabbits using a hydrogen gas clearance method and near-infrared spectrometry. Phenylephrine infusion led to an increase in blood pressure and cerebral blood flow without changes in cerebral blood volume and oxygenation. This result suggests that phenylephrine increases arterial blood flow and vascular resistance in vascular beds which may lead to the rupture of weak vessels in premature infants. Cytochrome a, a3, however, was not affected by the drug. Conversely, a low-dose dopamine infusion had no effect on cerebral hemodynamics, but high-dose decreased blood pressure and cerebral oxyhemoglobin, and increased deoxyhemoglobin without appreciable changes in cerebral blood flow, which suggests venous congestion and arterial blood reduction in the brain.
K Koyama, and
T Mito, and
S Takashima, and
S Suzuki
January 1989,
The American journal of physiology,
K Koyama, and
T Mito, and
S Takashima, and
S Suzuki
January 1995,
ORL; journal for oto-rhino-laryngology and its related specialties,
K Koyama, and
T Mito, and
S Takashima, and
S Suzuki
July 1993,
Journal of child neurology,
K Koyama, and
T Mito, and
S Takashima, and
S Suzuki
March 1987,
Postgraduate medical journal,
K Koyama, and
T Mito, and
S Takashima, and
S Suzuki
August 2004,
Journal of cardiothoracic and vascular anesthesia,
K Koyama, and
T Mito, and
S Takashima, and
S Suzuki
September 2000,
American journal of physiology. Heart and circulatory physiology,
K Koyama, and
T Mito, and
S Takashima, and
S Suzuki
January 1974,
Acta neurologica Scandinavica,
K Koyama, and
T Mito, and
S Takashima, and
S Suzuki
October 2008,
NeuroImage,
K Koyama, and
T Mito, and
S Takashima, and
S Suzuki
November 2005,
Magnetic resonance imaging,
K Koyama, and
T Mito, and
S Takashima, and
S Suzuki
September 1955,
Folia psychiatrica et neurologica japonica,
