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Correlations of antihypertensive and antisecretory activities with various structural modifications of the antihypertensive agent clonidine (2-(2,6-dichlorophenylimino)imidazolidine) are described. Eleven chemical classes of compounds containing an "amidine" moiety were prepared in this study. The antihypertensive activity of these compounds was evaluated in metacorticoid hypertensive rats and unanesthetized neurogenic hypertensive dogs following oral administration. Antisecretory activity was evaluated in fistula rats by measuring pH and volume of gastric secretion. Two compounds, 2-(2,6-dimethylphenylimino)imidazolidine and 2-(2,6-dichlorophenylimino)pyrrolidine, are particularly effective antisecretory agents with minimal antihypertensive activity.
T Jen, and
H Van Hoeven, and
W Groves, and
R McLean, and
B Loev
January 1999,
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques,
T Jen, and
H Van Hoeven, and
W Groves, and
R McLean, and
B Loev
January 1981,
European journal of pharmacology,
T Jen, and
H Van Hoeven, and
W Groves, and
R McLean, and
B Loev
June 1971,
Journal of medicinal chemistry,
T Jen, and
H Van Hoeven, and
W Groves, and
R McLean, and
B Loev
December 1977,
Journal of medicinal chemistry,
T Jen, and
H Van Hoeven, and
W Groves, and
R McLean, and
B Loev
December 1968,
The Journal of pharmacology and experimental therapeutics,
T Jen, and
H Van Hoeven, and
W Groves, and
R McLean, and
B Loev
May 1958,
Cancer research,
T Jen, and
H Van Hoeven, and
W Groves, and
R McLean, and
B Loev
April 2000,
European journal of medicinal chemistry,
T Jen, and
H Van Hoeven, and
W Groves, and
R McLean, and
B Loev
May 1957,
The Journal of clinical investigation,
T Jen, and
H Van Hoeven, and
W Groves, and
R McLean, and
B Loev
January 1983,
Clinical and experimental pharmacology & physiology,
T Jen, and
H Van Hoeven, and
W Groves, and
R McLean, and
B Loev
May 1989,
Archiv der Pharmazie,
