BIOMAT Database Logo BIOMAT Database Logo

Effects of preconditioning with normobaric hyperoxia on Na⁺/Ca²⁺ exchanger in the rat brain. 2013

E Mohammadi, and M R Bigdeli
Department of Physiology, Faculty of Biological Sciences, Shahid Beheshti University, GC, Tehran, Iran.

BACKGROUND Recent studies suggest that normobaric hyperoxia (HO) reduces hypoxia-reoxygenation injury in the rat brain. We have attempted to determine the effect of HO on Na(+)-Ca(2+) exchangers (NCX) in the rat stroke model. METHODS Rats were divided into two experimental groups. The first group was exposed to 95% inspired HO for 4h/day for 6 consecutive days (HO). The second group acted as the control, and was exposed to 21% oxygen in the same chamber. Each main group was subdivided to middle cerebral artery occlusion (MCAO-operated) and intact (without any surgery) subgroups. After 48 h from pretreatment, MCAO-operated subgroups were subjected to 60 min of right MCAO. After 24h reperfusion, neurologic deficit score (NDS) and infarct volume were measured in MCAO-operated subgroups. The NCXs expression levels of the core, penumbra and subcortical regions were assessed in sham-operated and intact subgroups. RESULTS Preconditioning with HO decreased NDS and infarct volume, and increased the expression of NCX1, NCX2 and NCX3 in the penumbra, NCX2, NCX3 in the core and NCX1 and NCX3 in the subcortex. CONCLUSIONS Although further studies are needed to clarify the mechanisms of ischemic tolerance, HO partly is associated with the expression of NCX1, 2, 3 consistent with an active role in the genesis of ischemic protection.

UI MeSH Term Description Entries
D008297 Male Males
D009460 Neurologic Examination Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system. Examination, Neurologic,Neurological Examination,Examination, Neurological,Examinations, Neurologic,Examinations, Neurological,Neurologic Examinations,Neurological Examinations
D010100 Oxygen An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. Dioxygen,Oxygen-16,Oxygen 16
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017078 Laser-Doppler Flowmetry A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates. Doppler-Laser Flowmetry,Flowmetry, Laser-Doppler,Laser-Doppler Velocimetry,Velocimetry, Laser-Doppler,Doppler Laser Flowmetry,Flowmetry, Doppler-Laser,Flowmetry, Laser Doppler,Laser Doppler Flowmetry,Laser Doppler Velocimetry,Velocimetry, Laser Doppler
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

E Mohammadi, and M R Bigdeli
Differential expression of Na/Ca exchanger and Na/Ca + K exchanger transcripts in rat brain.
November 2002, Annals of the New York Academy of Sciences,
E Mohammadi, and M R Bigdeli
Normobaric Hyperoxia Preconditioning Induces Changes in the Brain Lipidome.
January 2015, Current neurovascular research,
E Mohammadi, and M R Bigdeli
Normobaric hyperoxia preconditioning ameliorates cisplatin nephrotoxicity.
February 2014, Renal failure,
E Mohammadi, and M R Bigdeli
In vivo normobaric hyperoxia preconditioning induces different degrees of antioxidant enzymes activities in rat brain tissue.
June 2009, European journal of pharmacology,
E Mohammadi, and M R Bigdeli
[Normobaric hyperoxia in the rat].
January 1967, Anesthesie, analgesie, reanimation,
E Mohammadi, and M R Bigdeli
Preconditioning with prolonged normobaric hyperoxia induces ischemic tolerance partly by upregulation of antioxidant enzymes in rat brain tissue.
March 2009, Brain research,
E Mohammadi, and M R Bigdeli
[Na+/Ca+ exchanger].
October 2006, Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
E Mohammadi, and M R Bigdeli
Oxygen transport in the rat brain cortex at normobaric hyperoxia.
January 1999, European journal of applied physiology and occupational physiology,
E Mohammadi, and M R Bigdeli
Pro-oxidant effects of normobaric hyperoxia in rat tissues.
June 1992, Acta physiologica Scandinavica,
E Mohammadi, and M R Bigdeli
Effects of Na(+)/Ca(2+) exchanger downregulation on contractility and [Ca(2+)](i) transients in adult rat myocytes.
October 2002, American journal of physiology. Heart and circulatory physiology,
Copied contents to your clipboard!